Human Molecular Genetics, Vol 8, 639-644, Copyright © 1999 by Oxford University Press
R Shai, FP Quismorio Jr, L Li, OJ Kwon, J Morrison, DJ Wallace, CM Neuwelt, C Brautbar, WJ Gauderman and CO Jacob
Systemic lupus erythematosus (SLE) is the prototype of human autoimmune
diseases. Its genetic component has been suggested by familial aggregation
(lambdas = 20) and twin studies. We have screened the human genome to
localize genetic intervals that may contain lupus susceptibility loci in a
sample of 188 lupus patients belonging to 80 lupus families with two or
more affected relatives per family using the ABI Prism linkage mapping set
which includes 350 polymorphic markers with an average spacing of 12 cM.
Non-parametric multipoint linkage analysis suggests evidence for
predisposing loci on chromosomes 1 and 18. However, no single locus with
overwhelming evidence for linkage was found, suggesting that there are no
'major' susceptibility genes segregating in families with SLE, and that the
genetic etiology is more likely to result from the action of several genes
of moderate effect. Furthermore, the support for a gene in the 1q44 region
as well as in the 1p36 region is clearly found only in the Mexican American
families with SLE but not in families of Caucasian ethnicity, suggesting
that consideration of each ethnic group separately is crucial.
ARTICLES
Genome-wide screen for systemic lupus erythematosus susceptibility genes in multiplex families
Division of Rheumatology, Department of Medicine, University of Southern California School of Medicine, 2011 Zonal Avenue, HMR 711, Los Angeles, CA 90033, USA.
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