Human Molecular Genetics, Vol 8, 683-690, Copyright © 1999 by Oxford University Press
MP Lee, S Brandenburg, GM Landes, M Adams, G Miller and AP Feinberg
We previously reported the isolation of a 2.5 Mb tumor-suppressing
subchromosomal transferable fragment (STF) from human chromosome 11p15 and
the identification of nine known genes and four novel genes within this
STF. We now report the isolation of two novel cDNAs, designated here as
TSSC4 and TSSC6 (tumor-suppressing STF cDNA 4 and 6), located within the
STF. TSSC4 and TSSC6 encode predicted proteins of 329 and 290 amino acids,
respectively, with no close similarity to previously reported proteins.
TSSC4 and TSSC6 are both located in the center of a 1 Mb imprinted domain,
which contains the imprinted genes TSSC3, TSSC5, p57(KIP2), KVLQT1, ASCL2,
IGF2 and H19. However, we found that neither TSSC4 nor TSSC6 was
significantly imprinted in any of the fetal or extra-embryonic tissues
examined. Based on this result, the imprinted gene domain of 11p15 appears
to contain at least two imprinted subdomains, between which TSSC4 and TSSC6
substantially escape imprinting, due either to lack of initial silencing or
to an early developmental relaxation of imprinting.
ARTICLES
Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting
Department of Medicine, Johns Hopkins University School of Medicine, 1064 Ross, 720 Rutland Avenue, Baltimore, MD 21205, USA.
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