Human Molecular Genetics, Vol 8, 847-854, Copyright © 1999 by Oxford University Press
J Kim, X Lu and L Stubbs
In analysis of a conserved region of proximal mouse chromosome 7 and human
chromosome 19q, we have isolated a novel mouse gene, Zim1 (imprinted
zinc-finger gene 1), encoding a typical Kruppel-type (C2H2) zinc-finger
protein, located within 30 kb of a known imprinted gene, Peg3 (paternally
expressed gene 3). Our studies demonstrate that Zim1 is also imprinted; the
gene is expressed mainly from the maternal allele and at high levels only
during embryonic and neonatal stages. In contrast to most tissues, Zim1 is
expressed biallelically in neonatal and adult brain with slightly more
input from the maternal allele. Zim1 produces multiple transcripts that
range in size from 7.5 to 15 kb. The 7.5 kb transcript is expressed at
highest levels and appears to be embryo specific. Whole mount in situ
hybridization analysis indicates that Zim1 is expressed at significant
levels in the apical ectodermal ridge of the limb buds during
embryogenesis, suggesting a potential role of Zim1 in limb formation. We
have identified the potential human ortholog of Zim1 near PEG3 in a
conserved, gene-rich region of human chromosome 19q13.4. The close
juxtaposition of reciprocally imprinted genes has also been seen in other
imprinted regions, such as human 11p15.5/Mmu7 ( H19 / Igf2 ) and suggests
that the two genes may be co- regulated. These and other data suggest the
presence of an unexplored, conserved imprinted domain in human chromosome
19q13.4 and proximal Mmu7.
ARTICLES
Zim1, a maternally expressed mouse Kruppel-type zinc-finger gene located in proximal chromosome 7
Human Genome Center, Biology and Biotechnology Research Program, L-452, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551, USA. kim16@llnl.gov
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