Human Molecular Genetics, Vol 8, 1487-1490, Copyright © 1999 by Oxford University Press
K Kimura, E Noguchi, M Shibasaki, T Arinami, Y Yokouchi, K Takeda, K Yamakawa- Kobayashi, A Matsui and H Hamaguchi
Chromosome 13 contains several candidate genes for asthma and atopy, and
markers on this chromosome have been shown to be linked to phenotypes of
atopy or asthma in two genome-wide searches. We conducted a linkage study
for atopic asthma using markers spanning the whole of chromosome 13 in
Japanese families ascertained through asthmatic children and examined
associations of atopic asthma with markers where linkage was suggested.
Data were analysed using MAPMAKER/SIBS for the multipoint lod score (MLS)
analysis and SIB-PAIR for the transmission dis-equilibrium test (TDT).
Three peaks which exceeded a lod score of 1.0 were observed (MLS 2.4
between D13S175 and D13S217, MLS 2.0 between D13S153 and D13S156, and MLS
1.4 between D13S285 and D13S293). The global TDT for atopic asthma was
significant for the marker D13S153 ( P = 0.0065) and the 96 bp allele of
D13S153 was preferentially transmitted to atopic asthma-affected children (
P = 0.0009, Bonferroni correction 5% = 0. 0037, 1% = 0.00072). These
findings indicate that genes on chromosome 13 may play an important role in
the development of atopy or asthma across various populations.
ARTICLES
Linkage and association of atopic asthma to markers on chromosome 13 in the Japanese population
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.
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