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Human Molecular Genetics, 2000, Vol. 9, No. 16 2409-2419
© 2000 Oxford University Press

Counting cross-overs: characterizing meiotic recombination in mammals

Terry Hassold+, Stephanie Sherman1 and Patricia Hunt

Department of Genetics and the Center for Human Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA and 1Department of Genetics, Emory University School of Medicine, Atlanta, GA, USA

Until recently, most of our understanding of meiotic recombination has come from studies of lower eukaryotes. However, over the past few years several components of the mammalian meiotic recombination pathway have been identified, and new molecular and cytological approaches to the analysis of mammalian meiosis have been developed. In this review, we discuss recent advances in three areas: the application of new techniques to study genome-wide levels of recombination in individual meioses; studies analyzing temporal aspects of the mammalian recombination pathway; and studies linking the genesis of human trisomies to alterations in meiotic exchange patterns.

+ To whom correspondence should be addressed at: Department of Genetics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Tel: +1 216 368 3433; Fax: +1 216 368 0491; Email: tjh6@po.cwru.edu


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