Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Santos, F. R.
Right arrow Articles by Tyler-Smith, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Santos, F. R.
Right arrow Articles by Tyler-Smith, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, 2000, Vol. 9, No. 3 421-430
© 2000 Oxford University Press

A polymorphic L1 retroposon insertion in the centromere of the human Y chromosome

Fabrício R. Santos+, Arpita Pandya, Manfred Kayser1,§, R. John Mitchell2, Aiping Liu3, Lalji Singh4, Giovanni Destro-Bisol5, Andrea Novelletto6, Raheel Qamar7, S. Qasim Mehdi7, Raju Adhikari, Peter de Knijff8 and Chris Tyler-Smith{ddagger}

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK, 1Institut für Rechtsmedizin, Humboldt-Universität zu Berlin, Berlin, Germany, 2Unit of Human Genetics, School of Biochemistry and Genetics, La Trobe University, Bundoora, Victoria 3083, Australia, 3Auckland Cancer Research Centre, Faculty of Medicine and Health Science, University of Auckland, Private Bag 92019, Auckland, New Zealand, 4Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India, 5Dipartimento di Biologia Animale e dell’Uomo, Università ‘La Sapienza’, Roma, Italy, 6Department of Cell Biology, University of Calabria, Rende, Italy, 7Biomedical and Genetic Engineering Laboratories, PO Box 2891, Islamabad, Pakistan, 8Forensic Laboratory for DNA Research, MGC-Department of Human and Clinical Genetics, Leiden University Medical Center, PO Box 9503, 2300 RA Leiden, The Netherlands

We have identified a novel polymorphic L1 retroposon insertion, designated LY1, in the centromeric alphoid array of the human Y chromosome. The element belongs to the transpositionally active Ta subset and its presence is compatible with normal centromere function. It was found at highest frequency in China, where it accounts for 23% of the Han sample, and was present at low frequencies in the surrounding areas, but was not found at all outside Asia. Chromosomes carrying LY1 show considerable microsatellite diversity, suggesting an ancient origin for the lineage at ~10 000 years ago (with wide confidence limits), but only limited subsequent migration.

+ Present address: Departamento de Biologia Geral, ICB/UFMG, Caixa Postal 486, 31.270–910 Belo Horizonte, MG, Brazil

§ Present address: Max Planck Institute for Evolutionary Anthropology, Department of Evolutionary Genetics, Inselstrasse 22, D-04103 Leipzig, Germany

Present address: Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK

{ddagger} To whom correspondence should be addressed. Tel: +44 1865 275222; Fax: +44 1865 275259; Email: chris@bioch.ox.ac.uk


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
M. F. Hammer, T. M. Karafet, A. J. Redd, H. Jarjanazi, S. Santachiara-Benerecetti, H. Soodyall, and S. L. Zegura
Hierarchical Patterns of Global Human Y-Chromosome Diversity
Mol. Biol. Evol., July 1, 2001; 18(7): 1189 - 1203.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
O. Semino, G. Passarino, P. J. Oefner, A. A. Lin, S. Arbuzova, L. E. Beckman, G. D. Benedictis, P. Francalacci, A. Kouvatsi, S. Limborska, et al.
The Genetic Legacy of Paleolithic Homo sapiens sapiens in Extant Europeans: A Y Chromosome Perspective
Science, November 10, 2000; 290(5494): 1155 - 1159.
[Abstract] [Full Text]

Home page
 Genome ResHome page
F.-m. Sheen, S. T. Sherry, G. M. Risch, M. Robichaux, I. Nasidze, M. Stoneking, M. A. Batzer, and G. D. Swergold
Reading between the LINEs: Human Genomic Variation Induced by LINE-1 Retrotransposition
Genome Res., October 1, 2000; 10(10): 1496 - 1508.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.