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Human Molecular Genetics, 2000, Vol. 9, No. 6 861-868
© 2000 Oxford University Press

Autism: recent molecular genetic advances

Janine A. Lamb+, Janette Moore1, Anthony Bailey1 and Anthony P. Monaco

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK and 1MRC Child Psychiatry Unit, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK

Autism (MIM 209850) is a severe neuropsychiatric disorder of unknown aetiology with profound consequences for patients and their families. Strong evidence from twin and family studies indicates the importance of genetic factors in the development of idiopathic autism, although it is clear that these influences are complex. This review focuses on recent molecular investigations to identify susceptibility loci implicated in autistic disorder.

+ To whom correspondence should be addressed. Tel: +44 1865 287510; Fax +44 1865 287501; Email: janine.lamb@well.ox.ac.uk


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