Human Molecular Genetics Advance Access originally published online on July 21, 2005
Human Molecular Genetics 2005 14(17):2481-2483; doi:10.1093/hmg/ddi251
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
COMMENTARY |
Guidelines for association studies in Human Molecular Genetics
1Department of Psychiatry, 2Department of Human Genetics, UCLA Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, 695 Charles E. Young Drive South, Room 3506, Los Angeles, CA 90095-1761 and 3Department of Statistics, UCLA, 695 Charles E Young Aiwe South, Los Angeles, CA 90095-088, USA
* To whom correspondence should be addressed. Tel: +310 7949571; Fax: +310 7949613; Email: nfreimer@mednet.ucla.edu
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Introduction |
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The number of genetic association studies is growing rapidly, and this growth is likely to accelerate in the future. The correct interpretation of such studies has important implications for our understanding of disease causation, variability in drug response and drug side effects and the biology of populations. There is increasing awareness that the literature of association studies requires the application of stricter standards, to prevent the promulgation of false positive results. Although there is no single agreed upon set of standards for such studies, we believe that journals must, through the manuscripts that they choose to publish, promote an improvement in the quality of association studies. Guidelines can be an instrument for both authors and reviewers, to make such improvements. The subsequent guidelines should be followed for all future submissions to Human Molecular Genetics. The references provide background which may be useful for authors.
As the popularity of association studies
Candidate genes
Genome screens
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ACKNOWLEDGEMENTS |
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