Skip Navigation


Human Molecular Genetics Advance Access originally published online on July 21, 2005
Human Molecular Genetics 2005 14(17):2481-2483; doi:10.1093/hmg/ddi251
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
14/17/2481    most recent
ddi251v2
ddi251v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (32)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Freimer, N. B.
Right arrow Articles by Sabatti, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Freimer, N. B.
Right arrow Articles by Sabatti, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

COMMENTARY

Guidelines for association studies in Human Molecular Genetics

Nelson B. Freimer1,2,* and Chiara Sabatti2,3

1Department of Psychiatry, 2Department of Human Genetics, UCLA Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, 695 Charles E. Young Drive South, Room 3506, Los Angeles, CA 90095-1761 and 3Department of Statistics, UCLA, 695 Charles E Young Aiwe South, Los Angeles, CA 90095-088, USA

* To whom correspondence should be addressed. Tel: +310 7949571; Fax: +310 7949613; Email: nfreimer@mednet.ucla.edu

The first 150 words of the full text of this article appear below.


   Introduction
 
The number of genetic association studies is growing rapidly, and this growth is likely to accelerate in the future. The correct interpretation of such studies has important implications for our understanding of disease causation, variability in drug response and drug side effects and the biology of populations. There is increasing awareness that the literature of association studies requires the application of stricter standards, to prevent the promulgation of false positive results. Although there is no single agreed upon set of standards for such studies, we believe that journals must, through the manuscripts that they choose to publish, promote an improvement in the quality of association studies. Guidelines can be an instrument for both authors and reviewers, to make such improvements. The subsequent guidelines should be followed for all future submissions to Human Molecular Genetics. The references provide background which may be useful for authors.

As the popularity of association studies . . . [Full Text of this Article]

Candidate genes
Genome screens

   ACKNOWLEDGEMENTS
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CarcinogenesisHome page
K. E. Driver, H. Song, F. Lesueur, S. Ahmed, N. L. Barbosa-Morais, J. P. Tyrer, B. A.J. Ponder, D. F. Easton, P. D.P. Pharoah, A. M. Dunning, et al.
Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population
Carcinogenesis, February 1, 2008; 29(2): 333 - 341.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
J. P. Ioannidis, P. Boffetta, J. Little, T. R O'Brien, A. G Uitterlinden, P. Vineis, D. J Balding, A. Chokkalingam, S. M Dolan, W D. Flanders, et al.
Assessment of cumulative evidence on genetic associations: interim guidelines
Int. J. Epidemiol., February 1, 2008; 37(1): 120 - 132.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
D. D. G. Despriet, A. A. B. Bergen, J. E. Merriam, J. Zernant, G. R. Barile, R. T. Smith, I. A. Barbazetto, S. van Soest, A. Bakker, P. T. V. M. de Jong, et al.
Comprehensive Analysis of the Candidate Genes CCL2, CCR2, and TLR4 in Age-Related Macular Degeneration
Invest. Ophthalmol. Vis. Sci., January 1, 2008; 49(1): 364 - 371.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
T. R. Rebbeck, M. J. Khoury, and J. D. Potter
Genetic Association Studies of Cancer: Where Do We Go from Here?
Cancer Epidemiol. Biomarkers Prev., May 1, 2007; 16(5): 864 - 865.
[Full Text] [PDF]

Home page
 CarcinogenesisHome page
H. Song, S. J. Ramus, L. Quaye, R. A. DiCioccio, J. Tyrer, E. Lomas, D. Shadforth, E. Hogdall, C. Hogdall, V. McGuire, et al.
Common variants in mismatch repair genes and risk of invasive ovarian cancer
Carcinogenesis, November 1, 2006; 27(11): 2235 - 2242.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
T. Nakayama, N. Kuroi, M. Sano, Y. Tabara, T. Katsuya, T. Ogihara, Y. Makita, A. Hata, M. Yamada, N. Takahashi, et al.
Mutation of the Follicle-Stimulating Hormone Receptor Gene 5'-Untranslated Region Associated With Female Hypertension
Hypertension, September 1, 2006; 48(3): 512 - 518.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
E. Meaburn, L. M. Butcher, L. C. Schalkwyk, and R. Plomin
Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans
Nucleic Acids Res., February 14, 2006; 34(4): e28 - e28.
[Abstract] [Full Text] [PDF]