Human Molecular Genetics Advance Access originally published online on August 2, 2005
Human Molecular Genetics 2005 14(17):2489; doi:10.1093/hmg/ddi253
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COMMENTARY |
Interpreting gene-association studies
Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
* To whom correspondence should be addressed. Tel: +44 1865287601; Email: martin.farrall@well.ox.ac.uk
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Human gene mapping has made a crucial contribution to the positional cloning approach, which has identified the molecular basis of numerous inherited diseases. This research depended on the development of markers and experimental technologies (e.g. RFLPs and microsatellites), genomic