Human Molecular Genetics

Paediatric Molecular Genetics, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK

Received September 30, 1997; Accepted October 1, 1997

INTRODUCTION

As little as five years ago, the idea that it would be possible to generate an ovine model of cystic fibrosis (CF) was frequently met with humour and disbelief. Fortunately for those of us attempting to produce a large animal . . . [Full Text of this Article]

WHY DID THE CF MICE NOT LIVE UP TO EXPECTATION?

WHY SHOULD CF SHEEP BE ANY BETTER?

OTHER ADVANTAGES OF A CF SHEEP

WOULD ANY OTHER ANIMALS PROVIDE BETTER CF MODELS?

WILL IT BE POSSIBLE TO GENERATE A CF SHEEP?

SHOULD WE GENERATE A OVINE MODEL OF CF?

CAN WE AFFORD TO GENERATE AND MAINTAIN AN OVINE MODEL OF CF?

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