Human Molecular Genetics, 2003, Vol. 12, No. 7 803-804
DOI: 10.1093/hmg/ddg080
© 2003 Oxford University Press
The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function
Human Molecular Genetics, 11, 569–576 (2002)
In this Article, the role of polymorphisms in the MMP1, MMP9 and MMP12 genes in the rate of decline of lung function was studied. A rapid rate of decline was associated with the G-1607GG polymorphism and haplotypes consisting of alleles from the MMP1 G-1607GG and MMP12 Asn357Ser polymorphisms. Erroneously, the designation of the MMP1-1607 alleles was reversed throughout the article. The authors wish to apologize for this error, which affects one of the conclusions of the paper.
The seventh sentence of the abstract should read: The -1607GG allele was associated with a fast rate of decline (P=0.02).
The third and fourth sentences of the third paragraph of the results (page 570) should read: Possession of either one or two copies of the -1607GG allele was associated with a fast rate of decline (odds ratio=1.61, 95% CI 1.09–2.38, P=0.02). This association remained significant after adjustment for smoking history, age, sex and initial level of lung function (adjusted odds ratio=1.61, 95% CI 1.06–2.44, P=0.02).
The seventh paragraph of the discussion (page 572) should now read as follows: The frequency of the MMP1-1607G allele was decreased in the fast decliners (0.44) compared with the non-decliners (0.51) (Table 2). The -1607G allele is associated with decreased MMP1 gene expression and therefore this would be consistent with a protective effect against a rapid decline in lung function.
The eighth paragraph of the discussion (page 572) should read: The association of the MMP1 G-1607GG/MMP12 Asn357Ser haplotypes with rate of decline of lung function is not simply a consequence of the association of MMP1-1607GG with rapid decline since there is no LD between the two polymorphisms. Comparison of the haplotypes that were significantly increased or decreased in the fast decliners confirms that it is the combination of alleles rather than a single locus that is responsible for the association. MMP1-1607GG in combination with MMP12 Asn357 was significantly increased in the fast decliners, whereas MMP1-1607GG with MMP12 Ser357 was significantly decreased in the fast decliners. This suggests that MMP1-1607GG, by itself, is not the causal allele for this association. MMP12 Asn357Ser genotype was not associated with rate of decline of lung function (Table 3) suggesting that, by itself, this polymorphism is not causal.
The MMP1-1607 alleles should also be reversed in Tables 2, 3 and 4.
Additional labeling errors were made in Figure 1. The authors wish to apologize for any confusion this may have caused. The figure should appear as shown.
|
As a consequence of the labeling error Figure 2 should now appear as shown.
|
250 and 300 bp, G allele), 2 lower bands (
CiteULike 
Connotea 
Del.icio.us What's this?
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||