Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Milatovich, A.
Right arrow Articles by Francke, U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Milatovich, A.
Right arrow Articles by Francke, U.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 Oxford University Press

RESEARCH-ARTICLE

Serotonin receptor 1c gene assigned to X chromosome in human (band q24) and mouse (bands D-F4)

Athena Milatovich1, Chih-Lin Hsieh1,2, Giulia Bonaminio1, Larry Tecott3 and Uta Francke2,3,*

1Department of Genetics, Stanford University Medical Center Stanford, CA 94305 2Hughes Medical lnstitute, Stanford University Medical Center Stanford, CA 94305 3Department of Pharmacology, University of California San Francisco, CA 94143, USA

*To whom correspondence should be addressed at: Howard Hughes Medical Institute, Beckman Center for Molecular and Genetic Medicine, Stanford University Medical Center, Stanford, CA 94305-5428, USA

Received September 11, 1992; Revised October 16, 1992; Accepted October 16, 1992

In the mammalian nervous system, serotonin (5-hydroxy-tryptamine) binds to distinct cell surface receptor subtypes that are defined by their ligand binding and effector-coupling properties. The 5HT1c receptor is a G-protein coupled receptor that stimulates phospholipase C-catalyzed hydrolysis of phosphatidylinositol bisphosphate, leading to the mobilization of intracellular calcium and to the activation of protein kinase C. By using somatic cell hybnd analysis and FISH, we have mapped the HTR1C locus to the human X chromosome, hand q24 and to the mouse X chromosome region D-F4. Comparison of these map positions offers new insights into the evolution of human and murine X chromosomes. Since HTR1C is expressed in certain parts of the central nervous system and abnormal function of the serotoninergic system has been implicated in affective disorders, obsessive–compulsive disorder and epilepsy, establishing the precise map position of HTR1C is an important first step toward evaluating this locus as a candidate for mutations in these syndromes and in X-linked mental disorders.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
M. Öhman, L. Oksanen, J. Kaprio, M. Koskenvuo, P. Mustajoki, A. Rissanen, J. Salmi, K. Kontula, and L. Peltonen
Genome-Wide Scan of Obesity in Finnish Sibpairs Reveals Linkage to Chromosome Xq24
J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3183 - 3190.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. H. Tecott, S. F. Logue, J. M. Wehner, and J. A. Kauer
Perturbed dentate gyrus function in serotonin 5-HT2C receptor mutant mice
PNAS, December 8, 1998; 95(25): 15026 - 15031.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.