Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (53)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Service, S. K.
Right arrow Articles by Freimer, N. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Service, S. K.
Right arrow Articles by Freimer, N. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, 2001, Vol. 10, No. 5 545-551
© 2001 Oxford University Press

The genome-wide distribution of background linkage disequilibrium in a population isolate

Susan K. Service, Roel A. Ophoff and Nelson B. Freimer+

Center for Neurobehavioral Genetics, UCLA, Gonda Center, Room 3506, 695 Charles E. Young Drive South, Box 951761, Los Angeles, CA 90095-1761, USA

Recent interest in using association studies to investigate complex traits has focused attention on understanding linkage disequilibrium (LD) in the human genome. We examined the genome-wide distribution and magnitude of such background LD (BLD) using 1036 densely spaced microsatellites, in a sample from the demographically well characterized population of the Central Valley of Costa Rica. High levels of BLD were found between linked markers several centiMorgans apart, and although BLD was significantly related to genetic distance between markers it was not spread uniformly throughout the genome. Understanding the forces governing the distribution of BLD in the genome will require similar investigations using a standard set of markers in other populations.

+ To whom correspondence should be addressed. Tel: +1 310 794 9571; Fax: +1 310 794 9613; Email: nfreimer@mednet.ucla.edu


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
B. A. Raby, M. E. Soto-Quiros, L. Avila, S. L. Lake, A. Murphy, C. Liang, E. Fournier, M. Spesny, J. S. Sylvia, A. Verner, et al.
Sex-specific linkage to total serum immunoglobulin E in families of children with asthma in Costa Rica
Hum. Mol. Genet., February 1, 2007; 16(3): 243 - 253.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
F. M. De La Vega, H. Isaac, A. Collins, C. R. Scafe, B. V. Halldorsson, X. Su, R. A. Lippert, Y. Wang, M. Laig-Webster, R. T. Koehler, et al.
The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern
Genome Res., April 1, 2005; 15(4): 454 - 462.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
N. B. Sutter, M. A. Eberle, H. G. Parker, B. J. Pullar, E. F. Kirkness, L. Kruglyak, and E. A. Ostrander
Extensive and breed-specific linkage disequilibrium in Canis familiaris
Genome Res., December 1, 2004; 14(12): 2388 - 2396.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
R. L. Vallejo, Y. L. Li, G. W. Rogers, and M. S. Ashwell
Genetic Diversity and Background Linkage Disequilibrium in the North American Holstein Cattle Population
J Dairy Sci, December 1, 2003; 86(12): 4137 - 4147.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
P. Rahman, A. Jones, J. Curtis, S. Bartlett, L. Peddle, B. A. Fernandez, and N. B. Freimer
The Newfoundland population: a unique resource for genetic investigation of complex diseases
Hum. Mol. Genet., October 15, 2003; 12(90002): R167 - 172.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
P. Heutink and B. A. Oostra
Gene finding in genetically isolated populations
Hum. Mol. Genet., October 1, 2002; 11(20): 2507 - 2515.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
T. G. Schulze, Y.-S. Chen, N. Akula, K. Hennessy, J. A. Badner, M. G. McInnis, J. R. DePaulo, J. Schumacher, S. Cichon, P. Propping, et al.
Can long-range microsatellite data be used to predict short-range linkage disequilibrium?
Hum. Mol. Genet., June 1, 2002; 11(12): 1363 - 1372.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
I. Menashe, O. Man, D. Lancet, and Y. Gilad
Population differences in haplotype structure within a human olfactory receptor gene cluster
Hum. Mol. Genet., June 1, 2002; 11(12): 1381 - 1390.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
L. Tiret, O. Poirier, V. Nicaud, S. Barbaux, S.-M. Herrmann, C. Perret, S. Raoux, C. Francomme, G. Lebard, D. Tregouet, et al.
Heterogeneity of linkage disequilibrium in human genes has implications for association studies of common diseases
Hum. Mol. Genet., February 1, 2002; 11(4): 419 - 429.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
L.B. Jorde, W.S. Watkins, and M.J. Bamshad
Population genomics: a bridge from evolutionary history to genetic medicine
Hum. Mol. Genet., October 1, 2001; 10(20): 2199 - 2207.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. A. McInnes, S. K. Service, V. I. Reus, G. Barnes, O. Charlat, S. Jawahar, S. Lewitzky, Q. Yang, Q. Duong, M. Spesny, et al.
Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population
PNAS, September 25, 2001; 98(20): 11485 - 11490.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. Sobacchi, A. Frattini, P. Orchard, O. Porras, I. Tezcan, M. Andolina, R. Babul-Hirji, I. Baric, N. Canham, D. Chitayat, et al.
The mutational spectrum of human malignant autosomal recessive osteopetrosis
Hum. Mol. Genet., August 1, 2001; 10(17): 1767 - 1773.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.