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Human Molecular Genetics, 2001, Vol. 10, No. 7 677-685
© 2001 Oxford University Press

Telomerase and cancer

Jerry W. Shay1,+, Ying Zou1, Eiso Hiyama2 and Woodring E. Wright1

1The University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA and 2Department of General Medicine, Hiroshima University School of Medicine, Hiroshima, Japan

Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP maintains telomere length stability in almost all cancer cells. Over the past few years there has been significant progress in identifying the components of the telomerase holoenzyme complex and the proteins that associate with telomeres, in order to elucidate mechanisms of telomere length regulation. This review covers recent advances in the field including the use of telomerase in cancer diagnostics and an overview of anti-telomerase cancer therapeutic approaches.

+ To whom correspondence should be addressed. Tel: +1 214 648 3282; Fax: +1 214 648 8694; Email: jerry.shay@utsouthwestern.edu


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