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Human Molecular Genetics, 2002, Vol. 11, No. 17 1909-1910
© 2002 Oxford University Press
Microarrays and polyglutamine disorders: reports from the Hereditary Disease Array Group

Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
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Advances in molecular biology and genetics have allowed researchers to probe function and dysfunction at the level of the individual gene and/or protein. The integration of such information into an understanding of function has been a challenge facing all molecular geneticists and has contributed to the widening gap between molecular and systems scientists. In the neurosciences, this rift is especially dramatic. The ability to simultaneously monitor changes in the expression of thousands of genes using DNA microarrays has the potential to provide a global or genomic view of brain function/dysfunction.
Two important barriers in the application of this technology to the
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