Human Molecular Genetics, 2002, Vol. 11, No. 20 2447-2453
© 2002 Oxford University Press
Protecting genomic integrity during DNA replication: correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex
CNRS–UPR2169 Instabilité Génétique et Cancer, Institut de Recherches sur le Cancer André Lwoff, 7 Rue Guy Moquet, BP 8, 94801 Villejuif, France
Received July 8, 2002; Accepted July 15, 2002
DNA replication is a critical step for cells because of the propensity of replication forks to stall, as a consequence either of endogenous DNA damage or of the propensity of repeated sequences to form tertiary structures, which can impede fork progression. Moreover, as a result of stalled replication fork processing, potentially lethal and recombinogenic double-strand breaks can be formed. Thus cells (in particular human cells) have evolved a sophisticated network to deal with replication fork stall. Recently, WRN and BLM, two helicases mutated in the genetic hereditary conditions Werner and Bloom syndromes, appeared crucial for the correct recovery from replication arrest; however, it seems that other proteins assist them in this role. One of the possible partners is the MRE11 complex, which is found mutated in two other genetic instability syndromes: Nijmegen breakage syndrome and ataxia telangiectasia-like disorder. This strongly supports the idea of a central role of preventing crisis during DNA replication for the maintenance of genomic stability and integrity in human cells.
* To whom correspondence should be addressed. Tel: +33 149583409; Fax: +33 149583411; Email: pichier{at}vjf.cnrs.fr
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. E. Cohen, S. E. Pollack, and J. W. Pollard Genetic Analysis of Chromosome Pairing, Recombination, and Cell Cycle Control during First Meiotic Prophase in Mammals Endocr. Rev., June 1, 2006; 27(4): 398 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sobeck, S. Stone, V. Costanzo, B. de Graaf, T. Reuter, J. de Winter, M. Wallisch, Y. Akkari, S. Olson, W. Wang, et al. Fanconi Anemia Proteins Are Required To Prevent Accumulation of Replication-Associated DNA Double-Strand Breaks Mol. Cell. Biol., January 15, 2006; 26(2): 425 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Bailey and J. P. Murnane Telomeres, chromosome instability and cancer. Nucleic Acids Res., January 1, 2006; 34(8): 2408 - 2417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Rao, A. M. Fan, L. Meng, C. F. Doe, P. S. North, I. D. Hickson, and Y. Pommier Phosphorylation of BLM, Dissociation from Topoisomerase III{alpha}, and Colocalization with {gamma}-H2AX after Topoisomerase I-Induced Replication Damage Mol. Cell. Biol., October 15, 2005; 25(20): 8925 - 8937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Opresko, W.-H. Cheng, and V. A. Bohr Junction of RecQ Helicase Biochemistry and Human Disease J. Biol. Chem., April 30, 2004; 279(18): 18099 - 18102. [Full Text] [PDF]
|
|
|
|
|
|
S. L. Davies, P. S. North, A. Dart, N. D. Lakin, and I. D. Hickson Phosphorylation of the Bloom's Syndrome Helicase and Its Role in Recovery from S-Phase Arrest Mol. Cell. Biol., February 1, 2004; 24(3): 1279 - 1291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Zlotorynski, A. Rahat, J. Skaug, N. Ben-Porat, E. Ozeri, R. Hershberg, A. Levi, S. W. Scherer, H. Margalit, and B. Kerem Molecular Basis for Expression of Common and Rare Fragile Sites Mol. Cell. Biol., October 15, 2003; 23(20): 7143 - 7151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Opresko, W.-H. Cheng, C. von Kobbe, J. A. Harrigan, and V. A. Bohr Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. Carcinogenesis, May 1, 2003; 24(5): 791 - 802. [Abstract] [Full Text] [PDF]
|
|