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Human Molecular Genetics Advance Access originally published online on July 29, 2003
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Human Molecular Genetics, 2003, Vol. 12, No. 19 2411-2415
DOI: 10.1093/hmg/ddg251
© 2003 Oxford University Press

A unification of mosaic structures in the human genome

Martin J. Lercher1,*, Araxi O. Urrutia1, Adam Pavlícek2 and Laurence D. Hurst1

1Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK and 2Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 16637 Prague, Czech Republic

Received February 17, 2003; Accepted July 21, 2003

The human genome is a mosaic structure on many levels: there exist cytogenetic bands, GC composition bands (isochores) and clusters of broadly expressed genes. How might these inter-relate? It has been proposed that to optimize gene regulation, housekeeping genes should concentrate on transcriptionally competent chromosomal domains. Prior evidence suggests that regions of high GC and R bands are associated with such domains. Here we report that broadly expressed genes cluster in regions of high GC, and in R and lightest Giemsa bands. This is not only a confirmation of the adaptive hypothesis, but is also the first direct systematic evidence of a general interdependence of expression patterns with base composition and chromosome structure.

* To whom correspondence should be addressed. Tel: +44 1225385902; Fax: +44 1225386779; Email: m.j.lercher{at}bath.ac.uk


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