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Human Molecular Genetics, 2003, Vol. 12, Review Issue 2 R265-R270
DOI: 10.1093/hmg/ddg279
© 2003 Oxford University Press

The zebrafish as a model for muscular dystrophy and congenital myopathy

David I. Bassett1,* and Peter D. Currie2

1Comparative and Developmental Genetics Section, MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK and Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK and 2Victor Chang Cardiac Research Institute, 384 Victoria St, Darlinghurst 2010, Sydney, Australia

Received July 10, 2003; Accepted August 8, 2003

The muscular dystrophies and congenital myopathies are inherited diseases of the skeletal muscle, which lead to a loss of muscle function and are often fatal. While many of the loci involved are already known, these conditions remain incurable, and genetic models are being developed in an effort to understand the pathological mechanisms involved. Recently several papers have shown that the zebrafish, which is now widely used in developmental genetic studies, will provide a useful addition to our toolkit in this regard. Here we describe these studies, including a zebrafish model of what is potentially the novel pathological mechanism of muscle attachment failure in Duchenne and other muscular dystrophies.

* To whom correspondence should be addressed. Email: david.bassett{at}hgu.mrc.ac.uk


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