Skip Navigation


Human Molecular Genetics Advance Access originally published online on November 24, 2004
Human Molecular Genetics 2005 14(2):241-253; doi:10.1093/hmg/ddi022
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
14/2/241    most recent
ddi022v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (86)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Iwamoto, K.
Right arrow Articles by Kato, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iwamoto, K.
Right arrow Articles by Kato, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, Vol. 14, No. 2 © Oxford University Press 2005; all rights reserved

Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis

Kazuya Iwamoto, Miki Bundo and Tadafumi Kato*

Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan

* To whom correspondence should be addressed at: Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2-1, Wako, Saitama 351-0198, Japan. Tel: +81 484676949; Fax: +81 484676947; Email: kato{at}brain.riken.go.jp

Received August 18, 2004; Revised October 15, 2004; Accepted November 9, 2004

Accumulating evidence suggests that mitochondrial dysfunction underlies the pathophysiology of bipolar disorder (BD) and schizophrenia (SZ). We performed large-scale DNA microarray analysis of postmortem brains of patients with BD or SZ, and examined expression patterns of mitochondria-related genes. We found a global down-regulation of mitochondrial genes, such as those encoding respiratory chain components, in BD and SZ samples, even after the effect of sample pH was controlled. However, this was likely due to the effects of medication. Medication-free patients with BD showed tendency of up-regulation of subset of mitochondrial genes. Our findings support the mitochondrial dysfunction hypothesis of BD and SZ pathologies. However, it may be the expression changes of a small fraction of mitochondrial genes rather than the global down-regulation of mitochondrial genes. Our findings warrant further study of the molecular mechanisms underlying mitochondrial dysfunction in BD and SZ.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 DMMHome page
O. Malkesman, D. R. Austin, G. Chen, and H. K. Manji
Reverse translational strategies for developing animal models of bipolar disorder
Dis. Model. Mech., May 1, 2009; 2(5-6): 238 - 245.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
J. A. Lieberman, F. P. Bymaster, H. Y. Meltzer, A. Y. Deutch, G. E. Duncan, C. E. Marx, J. R. Aprille, D. S. Dwyer, X.-M. Li, S. P. Mahadik, et al.
Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection
Pharmacol. Rev., September 1, 2008; 60(3): 358 - 403.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
K. Iwamoto and T. Kato
Gene Expression Profiling in Schizophrenia and Related Mental Disorders
Neuroscientist, August 1, 2006; 12(4): 349 - 361.
[Abstract] [PDF]

Home page
 Hum Mol GenetHome page
N. Nakatani, E. Hattori, T. Ohnishi, B. Dean, Y. Iwayama, I. Matsumoto, T. Kato, N. Osumi, T. Higuchi, S.-I. Niwa, et al.
Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation
Hum. Mol. Genet., June 15, 2006; 15(12): 1949 - 1962.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Iwamoto, M. Bundo, K. Yamada, H. Takao, Y. Iwayama-Shigeno, T. Yoshikawa, and T. Kato
DNA Methylation Status of SOX10 Correlates with Its Downregulation and Oligodendrocyte Dysfunction in Schizophrenia
J. Neurosci., June 1, 2005; 25(22): 5376 - 5381.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.