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Human Molecular Genetics 2005 14(Review Issue 1):R1-R2; doi:10.1093/hmg/ddi118
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Editorial

Marisa S. Bartolomei and Wendy A. Bickmore

The first 10% of the full text of this article appears below.


   EPIGENETICS AND EPIGENOMES
 
Human Molecular Genetics is normally filled mostly with articles that relate changes in DNA sequence with disease pathologies. However, there has always been an appreciation in the journal that the regulation of gene expression and changes in chromatin structure also underpin normal human development and that perturbations of these can lead to disease.

The heritable changes in chromatin structure and gene expression that can be passed from one cell to its daughter cells fall under the umbrella term of ‘epigenetics’. Because DNA sequence alone does not describe our genetic information, a natural extension of the complete sequencing of the human genome is to ask whether we can also describe the ‘epigenome’, or more correctly the ‘epigenomes’, that even within one individual will vary between one somatic cell type and another and between normal and . . . [Full Text of this Article]


   EPIGENETIC REGULATION OF GENE EXPRESSION IN NEURONS
 

   EPIGENETIC RE-PROGRAMMING AND DEVELOPMENT
 

   EPIGENETICS AND CANCER
 

   EPIGENETIC MECHANISMS
 

   EPIGENETICS AND THE ENVIRONMENT
 

   ACKNOWLEDGEMENTS
 

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