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Human Molecular Genetics 2005 14(Review Issue 2):R157-R162; doi:10.1093/hmg/ddi273
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Gearing up for genome-wide gene-association studies

Martin Farrall1,* and Andrew P. Morris2

1Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK and 2Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

* To whom correspondence should be addressed at: Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK. Email: martin.farrall{at}well.ox.ac.uk

Received July 6, 2005; Accepted July 22, 2005

One of the grand challenges of human genetics to systematically map by gene-association susceptibility genes for complex diseases is underway. High-throughput genotyping platforms have been developed; a comprehensive map of human genetic variation (HapMap) to guide efficient marker selection is imminent and many researchers have assembled suitable cohorts of patients. Expectations are understandably high and it is timely to review the promise and pitfalls of this strategy.


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