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Human Molecular Genetics Advance Access originally published online on January 13, 2006
Human Molecular Genetics 2006 15(10):1563-1568; doi:10.1093/hmg/ddi481
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Genetic variation in DTNBP1 influences general cognitive ability

Katherine E. Burdick1,2,*, Todd Lencz1,2, Birgit Funke3, Christine T. Finn3, Philip R. Szeszko1,2, John M. Kane1,2, Raju Kucherlapati3 and Anil K. Malhotra1,2

1Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System and 2Department of Psychiatry, Albert Einstein College of Medicine, Glen Oaks, NY, USA and 3Harvard Partners Center for Genetics and Genomics, Boston, MA, USA

* To whom correspondence should be addressed at: Department of Psychiatry Research, The Zucker Hillside Hospital, North-Shore-Long Island Jewish Health System, 75-59 263rd Street, Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA. Tel: +1 7184708167; Fax: +1 7183431659; Email: kburdick{at}lij.edu

Received November 11, 2005; Accepted January 8, 2006

Human intelligence is a trait that is known to be significantly influenced by genetic factors, and recent linkage data provide positional evidence to suggest that a region on chromosome 6p, previously associated with schizophrenia, may be linked to variation in intelligence. The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder characterized by cognitive dysfunction. We report an association between DTNBP1 genotype and general cognitive ability (g) in two independent cohorts, including 213 patients with schizophrenia or schizo-affective disorder and 126 healthy volunteers. These data suggest that DTNBP1 genetic variation influences human intelligence.


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