Skip Navigation


Human Molecular Genetics Advance Access originally published online on September 19, 2006
Human Molecular Genetics 2006 15(21):3146-3153; doi:10.1093/hmg/ddl254
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Data
Right arrow All Versions of this Article:
15/21/3146    most recent
ddl254v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Herzberg, I.
Right arrow Articles by Ruiz-Linares, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Herzberg, I.
Right arrow Articles by Ruiz-Linares, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Convergent linkage evidence from two Latin-American population isolates supports the presence of a susceptibility locus for bipolar disorder in 5q31–34

Ibi Herzberg1, Anna Jasinska2, Jenny García3, Damini Jawaheer2, Susan Service2, Barbara Kremeyer1, Constanza Duque4, María V. Parra4, Jorge Vega4, Daniel Ortiz4, Luis Carvajal1, Guadalupe Polanco1, Gabriel J. Restrepo3, Carlos López3, Carlos Palacio3, Matthew Levinson2, Ileana Aldana2, Carol Mathews5, Pablo Davanzo6, Julio Molina2, Eduardo Fournier10, Julio Bejarano10, Magui Ramírez10, Carmen Araya Ortiz10, Xinia Araya10, Chiara Sabatti7,8, Victor Reus5, Gabriel Macaya10, Gabriel Bedoya4, Jorge Ospina3, Nelson Freimer2,6,9 and Andrés Ruiz-Linares1,4,*

1 Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK, 2 Center for Neurobehavioral Genetics, University of California, Los Angeles, CA, USA, 3 Departamento de Psiquiatría and 4 Laboratorio de Genética Molecular, Universidad de Antioquia, Medellín, Colombia, 5 Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA, 6 Department of Psychiatry and Behavioral Sciences, School of Medicine, 7 Department of Human Genetics and 8 Department of Statistics and 9 The Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA and 10 Cell and Molecular Biology Research Center and Escuela de Medicina, Universidad de Costa Rica, San José, Costa Rica

* To whom correspondence should be addressed. Tel: +44 2076795049; Fax: +44 2076795052; Email: a.ruizlin{at}ucl.ac.uk

Received June 29, 2006; Revised August 14, 2006; Accepted September 8, 2006

We performed a whole genome microsatellite marker scan in six multiplex families with bipolar (BP) mood disorder ascertained in Antioquia, a historically isolated population from North West Colombia. These families were characterized clinically using the approach employed in independent ongoing studies of BP in the closely related population of the Central Valley of Costa Rica. The most consistent linkage results from parametric and non-parametric analyses of the Colombian scan involved markers on 5q31–33, a region implicated by the previous studies of BP in Costa Rica. Because of these concordant results, a follow-up study with additional markers was undertaken in an expanded set of Colombian and Costa Rican families; this provided a genome-wide significant evidence of linkage of BPI to a candidate region of ~10 cM in 5q31–33 (maximum non-parametric linkage score=4.395, P<0.00004). Interestingly, this region has been implicated in several previous genetic studies of schizophrenia and psychosis, including disease association with variants of the enthoprotin and gamma-aminobutyric acid receptor genes.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arch Gen PsychiatryHome page
R. H. Perlis, S. Purcell, J. Fagerness, A. Kirby, T. L. Petryshen, J. Fan, and P. Sklar
Family-Based Association Study of Lithium-Related and Other Candidate Genes in Bipolar Disorder
Arch Gen Psychiatry, January 1, 2008; 65(1): 53 - 61.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.