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Human Molecular Genetics 2007 16(R1):R28-R49; doi:10.1093/hmg/ddm021
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Cancer genetics of epigenetic genes

Ahmad Miremadi1, Mikkel Z. Oestergaard2, Paul D.P. Pharoah1,2 and Carlos Caldas1,*

1 Cancer Genomics Program, Department of Oncology, Hutchison/MRC Research Centre and 2 Department of Public Health, Strangeways Research Laboratories, University of Cambridge, Cambridge, UK

* To whom correspondence should be addressed at: Breast Cancer Functional Genomics Laboratory, Cancer Research UK, Cambridge Research Institute and Department of Oncology, University of Cambridge, Li Ka-Shing Centre, Robinson Way, Cambridge CB2 0RE, UK. Email: cc234{at}cam.ac.uk

Received January 9, 2007; Revised February 7, 2007; The cancer epigenome is characterised by specific DNA methylation and chromatin modification patterns. The proteins that mediate these changes are encoded by the epigenetics genes here defined as: DNA methyltransferases (DNMT), methyl-CpG-binding domain (MBD) proteins, histone acetyltransferases (HAT), histone deacetylases (HDAC), histone methyltransferases (HMT) and histone demethylases. We review the evidence that these genes can be targeted by mutations and expression changes in human cancers.


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