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Human Molecular Genetics 2008 17(R1):R28-R36; doi:10.1093/hmg/ddn149
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Human Molecular Genetics issue: Stem Cells and Regeneration [View the issue table of contents]

Epigenetic regulation of stem cell fate

Victoria V. Lunyak1,* and Michael G. Rosenfeld2

1 Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA 2 Howard Hughes Medical Institute, Department of Molecular Medicine, School of Medicine, University of California, 9500 Gilman Drive, Rm 345, La Jolla, San Diego, CA 92093-0648, USA

* To whom correspondence should be addressed. Tel: +1 4152092000; Fax: +1 4158991810; Email: vlunyak{at}buckinstitute.org

Received February 13, 2008; Revised April 18, 2008; Accepted May 2, 2008

Stem cell-based regenerative medicine holds great promise for repair of diseased tissue. Modern directions in the field of epigenetic research aimed to decipher the epigenetic signals that give stem cells their unique ability to self-renew and differentiate into different cell types. However, this research is only the tip of the iceberg when it comes to writing an ‘epigenetic instruction manual’ for the ramification of molecular details of cell commitment and differentiation. In this review, we discuss the impact of the epigenetic research on our understanding of stem cell biology.


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