Skip Navigation


Human Molecular Genetics Advance Access originally published online on April 9, 2009
Human Molecular Genetics 2009 18(13):2518-2522; doi:10.1093/hmg/ddp177
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Data
Right arrowOA All Versions of this Article:
18/13/2518    most recent
ddp177v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Barton, A.
Right arrow Articles by Worthington, J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barton, A.
Right arrow Articles by Worthington, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes

Anne Barton1,*,{dagger}, Steve Eyre1,{dagger}, Xiayi Ke1, Anne Hinks1, John Bowes1, Edward Flynn1, Paul Martin1, YEAR Consortium{ddagger}, BIRAC Consortium{ddagger}, Anthony G. Wilson2, Ann W. Morgan3, Paul Emery3, Sophia Steer4, Lynne J. Hocking5, David M. Reid5, Pille Harrison6, Paul Wordsworth6, Wendy Thomson1 and Jane Worthington1

1 arc-Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK 2 School of Medicine & Biomedical Sciences, Sheffield University, Sheffield S10 2JF, UK 3 Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK 4 Clinical and Academic Rheumatology, Kings College Hospital NHS Foundation Trust, Denmark Hill SE5 9RS, London, UK 5 Musculoskeletal and Genetics Section, Division of Applied Medicine, University of Aberdeen, Aberdeen AB25 2ZD, UK, 6 Botnar Research Centre, Institute of Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK

* To whom correspondence should be addressed. Tel: +44 1612755037; Fax: +44 1612755043; Email: anne.barton{at}manchester.ac.uk

Received February 9, 2009; Accepted April 6, 2009

The concept of susceptibility genes common to different autoimmune diseases is now firmly established with previous studies demonstrating overlap of loci conferring susceptibility to type 1 diabetes (T1D) with both Coeliac disease and multiple sclerosis. Rheumatoid arthritis (RA) is an archetypal autoimmune disease and we, therefore, targeted putative T1D susceptibility loci for genotyping in UK RA cases and unrelated controls. A novel RA susceptibility locus at AFF3 was identified with convincing evidence for association in a combined sample cohort of 6819 RA cases and 12 650 controls [OR 1.12 95% confidence intervals (CI) 1.07–1.17, P = 2.8 x 10–7]. Association of two previously described loci (CTLA-4 and 4q27) with RA was also replicated (OR 0.87, 95% CI 0.82–0.94, P = 1.1 x 10–4 and OR 0.86, 95% CI 0.79–0.94, P = 5.4 x 10–4, respectively). These findings take the number of established RA susceptibility loci to 13, only one of which has not been associated with other autoimmune diseases.

{dagger} These two authors contributed equally to the work.

{ddagger} Supplementary note online.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.