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© 1993 Oxford University Press

RESEARCH-ARTICLE

The major peripheral myelin protein zero gene: structure and localization in the cluster of Fc{gamma} receptor genes on human chromosome 1q21.3 – q23

Danielle Pham-Dinh, Yves Fourbil1, Francolse Blanquet, Marie-Geneviève Mattél2, Nathalie Roeckel2, Philippe Latour1, Guy Chazot1, Antoon Vandenberghe1,3 and André Dautigny*

Equipe ATIPE, Centre National de la Recherche Scientifique Unite 1488, Institut des Neurosciences, Université de Paris VI borte 12, Batiment B, 9 Quai Saint-Bernard, F-75252 Paris Cedex 05, France 1Laboratore de Neurogénétique, Hopital de I'Antiquaille F–69321 Lyon Cedex 05, France 2Institut National de la Santé et de la Recherche Médicale, Unité 242, Hopital d'Enfants de la Timone F-13385 Marseille Cedex 05, France 3Faculté de Pharmacie, Université Claude Bernard Lyon I F-69008 Lyon, France

*To whom correspondence should be addressed

Received August 9, 1993; Revised October 14, 1993; Accepted October 14, 1993

We have characterized the human gene encoding the major peripheral myelin protein zero (PO) and assigned it, by In situ hybridization, to the q21.3–q23 region of human chromosome 1. This region is known to contain a cluster of Interspersed genes coding for the related human leukocyte receptors of the Fc portion of the Immunoglobulin G (Fc{gamma}RI, II, III). This colocalization was refined by the finding of a yeast artificial chromosome (YAC) of the Centre d'Etude du Polymorphisme Humain (CEPH) library, hybridizing to the PO and Fc{gamma}RIIA genes, demonstrating their physical linkage. These data may have important implications in demyelinating diseases studies like Charcot — Marie — Tooth disease type 1B (CMT1B).


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