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© 1993 Oxford University Press

RESEARCH-ARTICLE

Dystrophin expression improves myofiber survival in mdx muscle following intramuscular plasmid DNA injection

Istvan Danko, Jeffery D. Fritz, Jeffrey S. Latendresse, Hans Herweijer, Edward Schultz1 and Jon A. Wolff*

Departments of Pediatrics and Medical Genetics, Waisman Center, University of Wisconsin – Madison Madison, Wl 53705 1Department of Anatomy, University of Wisconsin-Madison Madison, Wl 53706, USA

*To whom correspondence should be addressed at: Waisman Center, Room 355, 1500 Highland Avenue, Madison, WI 53705, USA

Received August 11, 1993; Revised September 20, 1993; Accepted October 5, 1993

Expression of Becker-like and full-length human dystrophlns was stable for at least 6 months In mdx mouse muscle following Intramuscular plasmid DNA Injection. Intramuscular Injection of a single plasmld DNA encoding both luciferase and dystrophln resulted In stable luclferase expression for at least 2 months in mdx muscle, whereas Injection of plasmld DNA encoding only luclferase did not result In stable luclferase expression. These results suggest that expression of either full-length or Becker-like dystrophlns protects mdx mouse myoflbers from degeneration.


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