© 1993 Oxford University Press
RESEARCH-ARTICLE |
Genomic organization of the sequence coding for fibrillin, the defective gene product in Marfan syndrome
Brookdale Center for Molecular Biology, Mount Sinai School of Medicine 1 Gustave L. Levy Place, New York, NY 10029, USA 1University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital Headington, Oxford OX3 9DU, UK 2Department of Pathology, Howard Hughes Medical Institute, University of Michigan Medical Center Ann Arbor, Ml 48109, USA
*To whom correspondence should be addressed
Received March 8, 1993; Revised April 23, 1993; Accepted April 23, 1993
Marfan syndrome results from mutations in an extracellular matrix glycoprotein, fibrillin. Previous studies have characterized 
6.9-kb of the estimated 10-kb fibrillin transcript. We have now completed the primary structure of fibrillin, elucidated the exon/intron organization of the gene and derived a physical map of the genetic locus. Pre-fibrillin consists of 2, 871 amino acids which, excluding the signal peptide, are arranged into five structurally distinct regions. The largest of these regions comprises about 75% of the entire protein and consists of numerous repeated cysteine-rich sequences homologous to the peptide motifs of the epidermal growth factor (EGF) and transforming growth factor-ß binding protein (TGF-bp). Forty-three of the forty-six EGF-like repeats contain a calcium binding consensus sequence (EGF-CB) conceivably mediatin - protein interactions. Fibrillin exhibits a few additional cysteine-rich modules that are apparently unique to this macromolecule and may represent evolutionary variants of the EGF-CB and TGF-bp motifs. Almost all of the cysteine-rich repeats are encoded by single exons; consequently, the fibrillin gene is relatively large (110-kb) and highly fragmented (65 exons). This study provides the first comprehensive analysis of the fibrillin gene and relevant information for the full characterization of Marfan syndrome mutations.
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