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© 1994 Oxford University Press

OTHER

The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons

Carole A. Sargent, Craig Young, Sharon Marsh, Malcolm A. Ferguson-Smith and Nabeel A. Affara*

Human Molecular Genetics Group, University of Cambridge Department of Pathology Tennis Court Road, Cambridge CB2 1QP, UK

* To whom correspondence should be addressed

Received April 5, 1994; Accepted May 18, 1994

The human glycerol kinase gene family consists of at least six genomlc loci, four of which encode expressed sequences. The X-linked gene responsible for GKD maps to Xp21.3. Analysis of cosmid and YAC clones shows that this locus is In excess of 50 kbp, and is comprised of 19 exons. In contrast, the remaining members of the gene family, on chromosomes 1, 4 and Xq, appear to be organized as Intronless genes. Northern analysis shows expression of GK transcripts of three sizes in a wide range of adult tissues. Only the smallest hybridizing species is present in testis where it occurs at an elevated level. Two different testis transcripts have been identified and both of these originate from chromosome 4.


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