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© 1994 Oxford University Press

OTHER

Isolation of a diverged homeobox gene, M0X1, from the BRCA1 region on 17q21 by solution hybrid capture

P.Andrew Futreal*, Charles Cochran, Judith Rosenthal1, Yoshlo Miki2, Jeff Swenson2, Maurine Hobbs1,3, L.Michelle Bennett, Astrid Haugen-Strano, Jeff Marks4, J.Carl Barrett, Sean V. Tavtlglan1, Donna Shattuck-Eldens1, Alexander Kamb1, Mark Skolnick1,2 and Roger W. Wiseman

Laboratory of Motecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park, NC 27709 1Myriad Genetics, Inc. 421 Wakara Way, Salt Lake City, UT 84108 2Department of Medical Informatics 3Department of Human Genetics, University of Utah Medical Center Salt Lake City, UT 84132 4Department of Surgery, Duke University Medical Center, Duke University Durham, NC 27710, USA

* To whom correspondence should be addressed

Received March 13, 1994; Accepted June 16, 1994

Using the technique of solution hybridization coupled with magnetic bead capture, we have isolated a novel homeobox-containing gene from the BRCA1 region of 17q21. This gene is the human homologue of the mouse Mox1 gene previously localized to a syntenic region of mouse chromosome 11. Multiple overlapping cDNAs of human M0X1 were Identified using both a cosmid and a P1 genomic clone containing the microsatellite markers D17S750 and D17S858 which map within the BRCA1 region defined by D17S776 and D17S78. M0X1 expression was observed In a variety of normal tissues examined, Including breast and ovary. Given that the gene contains a homeobox domain and has the potential to regulate growth and differentiation, M0X1 represents an attractive candidate for the BRCA1 gene. This possibility was Investigated in a series of BRCA1 kindreds and primary sporadic breast tumors. No evidence for mutation was found In the coding sequence, making It unlikely that M0X1 Is the BRCA1 gene. However, the widespread expression of M0X1 in non-embryonal tissues suggests a role In normal cell biology which warrants further study.


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