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© 1994 Oxford University Press

OTHER

Localization of a gene for autosomal dominant amelogenesis imperfecta (ADAI) to chromosome 4q

Kristina Forsman1,2,*, Lisbet Lind1,2, Birgitta Bäckman3, Eleonora Westermark1,2 and Gösta Holmgren1,2

1Department of Clinical Genetics, University Hospital S-901 85 Umeå 2Department of Applied Cell and Molecular Biology, University of Umeå S-901 87 Umeå, Sweden 3Department of Pedodontics, University of Umeå S-901 87 Umeå, Sweden

*To whom correspondence should be addressed

Received May 18, 1994; Revised July 6, 1994; Accepted July 6, 1994

Amelogenesis imperfecta (Al), is an inherited odontological disease which affects the formation of enamel. We report a linkage analysis study performed on three Swedish families, where the affected members had an autosomal dominant variant of Al (ADAI) clinically characterized as local hypoplastic. Significant linkage to microsatellite markers on chromosome 4q were obtained. Recombinations localized the ADAI locus to a chromosome region which contains both a locus for the dental disorder dentinogenesis imperfecta and the albumin gene. Serum albumin has been suggested to play a role in enamel formation, and the albumin gene is therefore a candidate gene for this genetic disease.


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