Human Molecular Genetics, Vol 5, 1713-1726, Copyright © 1996 by Oxford University Press
MC Simmler, DB Cunningham, P Clerc, T Vermat, B Caudron, C Cruaud, A Pawlak, C Szpirer, J Weissenbach, JM Claverie and P Avner
X chromosome inactivation in both mouse and human requires the presence of
a cis acting locus, the X inactivation centre. This locus is thought to be
involved in the initiation and spreading of the inactivation signal in
early development. In order to increase our understanding of the mouse X
inactivation centre, a 94 kb region immediately distal to the Xist gene has
been sequenced and analysed for the presence of transcription units and/or
potential cis acting regulatory elements. We have identified a novel gene,
Tsx, lying 40 kb 3' from Xist. Tsx is expressed specifically in the testis
and shows no convincing homology to proteins currently in the databases. A
rat homologue, also X linked, has been isolated. The mouse and rat Tsx
sequences are highly divergent, suggesting that part of the X inactivation
centre, including both Xist and Tsx are subject to relatively weak
evolutionary constraints.
ARTICLES
A 94 kb genomic sequence 3' to the murine Xist gene reveals an AT rich region containing a new testis specific gene Tsx
CNRS URA1968, Genetique Moleculaire Murine, Institut Pasteur, Paris, France.
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