Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (23)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Arlt, M. F.
Right arrow Articles by Goodfellow, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arlt, M. F.
Right arrow Articles by Goodfellow, P. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, Vol 5, 1017-1021, Copyright © 1996 by Oxford University Press

ARTICLES

Frequent deletion of chromosome 1p sequences in an aggressive histologic subtype of endometrial cancer

MF Arlt, TJ Herzog, DG Mutch, DJ Gersell, H Liu and PJ Goodfellow
Department of Surgery, Washington University School of Medicine, St Louis MO 63110, USA.

The molecular genetic events underlying endometrial tumorigenesis are ill-defined at present. We have identified a region on the short arm of chromosome 1 which is frequently deleted in endometrial cancers. The region of deletion has been localized to bands 1p32-33. Deletion of 1p32-33 is seen more frequently in cancers of the highly aggressive papillary serous type than in cancers of the less-aggressive endometrioid type. These data suggest the presence of a tumor suppressor gene on 1p32-33 which is specifically involved in the development of endometrial cancers with poor outcome.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JCOHome page
P. E. Grundy, N. E. Breslow, S. Li, E. Perlman, J. B. Beckwith, M. L. Ritchey, R. C. Shamberger, G. M. Haase, G. J. D'Angio, M. Donaldson, et al.
Loss of Heterozygosity for Chromosomes 1p and 16q Is an Adverse Prognostic Factor in Favorable-Histology Wilms Tumor: A Report From the National Wilms Tumor Study Group
J. Clin. Oncol., October 10, 2005; 23(29): 7312 - 7321.
[Abstract] [Full Text] [PDF]

Home page
 INT J SURG PATHOLHome page
S. X. Liang, S. K. Chambers, L. Cheng, S. Zhang, Y. Zhou, and W. Zheng
Endometrial Glandular Dysplasia: A Putative Precursor Lesion of Uterine Papillary Serous Carcinoma. Part II: Molecular Features
International Journal of Surgical Pathology, October 1, 2004; 12(4): 319 - 331.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
Y.-J. Chen, A. Vortmeyer, Z. Zhuang, S. Huang, and R. T. Jensen
Loss of Heterozygosity of Chromosome 1q in Gastrinomas: Occurrence and Prognostic Significance
Cancer Res., February 15, 2003; 63(4): 817 - 823.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
H Tonnies, M R Toliat, C Ramel, U F Pape, H Neitzel, W Berger, and B Wiedenmann
Analysis of sporadic neuroendocrine tumours of the enteropancreatic system by comparative genomic hybridisation
Gut, April 1, 2001; 48(4): 536 - 541.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.