Human Molecular Genetics, Vol 5, 869-874, Copyright © 1996 by Oxford University Press
DJ Elliott, K Ma, SM Kerr, R Thakrar, R Speed, AC Chandley and H Cooke
We have isolated a murine homologue of the human Y-linked RBM genes
(previously termed YRRM), a gene family implicated in spermatogenesis and
which encodes proteins containing an RNA recognition motif. A number of
very similar copies of this gene (called Rbm) are present in the mouse.
These mouse homologues are also Y-encoded, mapping on the short arm of the
chromosome, proximal to Sry. Expression is confined to the testis,
specifically the germ line on the basis of lack of expression in the
germ-line negative testes of adult sex-reversed mice. The timing of Rbm
transcription is regulated, with fetal message levels reaching a peak at 15
d.p.c. Transcripts are clearly detectable by 4 days after birth and reach
their highest level at 14 d.p.p. which is the time at which the Y
chromosome condenses during meiotic prophase. These results suggest that
Rbm is functionally involved in germline RNA metabolism.
ARTICLES
An RBM homologue maps to the mouse Y chromosome and is expressed in germ cells
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.
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