Human Molecular Genetics, Vol 5, 1207-1216, Copyright © 1996 by Oxford University Press
N Ben-Arie, AE McCall, S Berkman, G Eichele, HJ Bellen and HY Zoghbi
atonal is a Drosophila proneural gene that belongs to the family of basic
helix-loop-helix (bHLH)- containing proteins. It is expressed in the
chordotonal organs and photoreceptor cells, and flies that lack Atonal
protein are ataxic and blind. Here we report the cloning of atonal homologs
from red flour beetle, puffer fish, chicken, mouse, and human. The bHLH
domain is conserved throughout evolution, while the entire coding region is
highly similar in mammals. Both the chicken and the mouse homologs are
expressed early in embryogenesis in the hind brain, and specifically in
cells predicted to give rise to the external granular layer of the
cerebellum. In addition, these genes are expressed throughout the dorsal
part of the spinal cord, in patterns different from those found for other
genes, like LH-2 and wnt-1. The mouse homolog (Math1) maps to mouse
chromosome 6, and the human homolog (HATH1) to human chromosome 4q22. Two
neurological mouse mutants, Lc and chp, were found to map to the vicinity
of Math1, but are not caused by mutations in Math1. The evolutionary
conservation of this gene and its mRNA expression patterns during
embryogenesis suggests that it plays a key role in the development of the
vertebrate central nervous system.
ARTICLES
Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.
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