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Human Molecular Genetics, Vol 6, 1693-1698, Copyright © 1997 by Oxford University Press

REVIEWS

Genetics of multiple sclerosis [published erratum appears in Hum Mol Genet 1997 Nov;6(12):2189]

DA Dyment, AD Sadovnick, GC Ebers and AD] Sadnovich AD$[corrected to Sadovnick
Department of Biochemistry, University of Western Ontario, London, Canada.

Multiple Sclerosis (MS) is a common chronic central nervous system disease in young adults. Relative familial risk appears to be determined largely by genes while population risk is strongly influenced by environmental factors. This is supported by genetic epidemiological studies which also suggest an oligogenic inheritance of susceptibility. The HLA DRB1*1501, DQA1*0102, DQB1 0602 haplotype is associated with the disease but HLA contributes only modestly to overall susceptibility. The results of three genomic searches are concordant with the genetic epidemiology and imply a number of genes with interacting effects will be found. Importantly, no single region has been identified with a major influence on familial risk.
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