Human Molecular Genetics, Vol 6, 2077-2085, Copyright © 1997 by Oxford University Press
C Julier, M Delepine, B Keavney, J Terwilliger, S Davis, DE Weeks, T Bui, X Jeunemaitre, G Velho, P Froguel, P Ratcliffe, P Corvol, F Soubrier and GM Lathrop
Hypertension is a significant risk factor for heart attack and stroke and
represents a major public health burden because of its high prevalence
(e.g. 15-20% of the European and American populations). Although blood
pressure is known to have a strong genetic determination, the genes
responsible for susceptibility to essential hypertension are mostly
unknown. Loci involved in blood pressure regulation have been found by
linkage in experimental hereditary hypertensive rat strains, but their
relationship to human hypertension has not been extensively investigated.
One of the principal blood pressure loci has been mapped to rat chromosome
10 and we have undertaken an investigation of the homologous region on
human chromosome 17 in familial essential hypertension. Affected sib-pair
analysis and parametric analysis with ascertainment correction gave
significant evidence of linkage ( P <0.0001 in some analyses) near two
closely linked microsatellite markers, D17S183 and D17S934, that reside 18
cM proximal to the ACE locus in the homology region. Our results indicate
that chromosome 17q could contain a susceptibility locus for human
hypertension and show that comparative mapping may be a useful approach for
identification of such loci in humans.
ARTICLES
Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10
The Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Road, Oxford OX3 7LD, UK. cecile@well.ox.ac.uk
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. K. Arnett, A. E. Baird, R. A. Barkley, C. T. Basson, E. Boerwinkle, S. K. Ganesh, D. M. Herrington, Y. Hong, C. Jaquish, D. A. McDermott, et al. Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease: A Scientific Statement From the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group Circulation, June 5, 2007; 115(22): 2878 - 2901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. I. Rice, A. L. Jones, P. J. Grant, A. M. Carter, A. J. Turner, and N. M. Hooper Circulating Activities of Angiotensin-Converting Enzyme, Its Homolog, Angiotensin-Converting Enzyme 2, and Neprilysin in a Family Study Hypertension, November 1, 2006; 48(5): 914 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Guzman, B. Cormand, M. Ribases, D. Gonzalez-Nunez, A. Botey, and E. Poch Implication of Chromosome 18 in Hypertension by Sibling Pair and Association Analyses: Putative Involvement of the RKHD2 Gene Hypertension, November 1, 2006; 48(5): 883 - 891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Franceschini, J. W. MacCluer, H. H.H. Goring, S. A. Cole, K. M. Rose, L. Almasy, V. Diego, S. Laston, E. T. Lee, B. V. Howard, et al. A Quantitative Trait Loci-Specific Gene-by-Sex Interaction on Systolic Blood Pressure Among American Indians: The Strong Heart Family Study Hypertension, August 1, 2006; 48(2): 266 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Nestor, G. T. Cicila, S. E. Karol, K. M. Langenderfer, S. L. Hollopeter, and D. C. Allison Linkage analysis of neointimal hyperplasia and vascular wall transformation after balloon angioplasty Physiol Genomics, April 13, 2006; 25(2): 286 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hadchouel, C. Delaloy, S. Faure, J.-M. Achard, and X. Jeunemaitre Familial Hyperkalemic Hypertension J. Am. Soc. Nephrol., January 1, 2006; 17(1): 208 - 217. [Full Text] [PDF]
|
|
|
|
|
|
S. Charron, C. Duong, A. Menard, J. Roy, V. Eliopoulos, R. Lambert, and A. Y. Deng Epistasis, Not Numbers, Regulates Functions of Clustered Dahl Rat Quantitative Trait Loci Applicable to Human Hypertension Hypertension, December 1, 2005; 46(6): 1300 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Kraja, D. C. Rao, A. B. Weder, R. Cooper, J. D. Curb, C. L. Hanis, S. T. Turner, M. de Andrade, C. A. Hsiung, T. Quertermous, et al. Two Major QTLs and Several Others Relate to Factors of Metabolic Syndrome in the Family Blood Pressure Program Hypertension, October 1, 2005; 46(4): 751 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Catarsi, R. Ravazzolo, F. Emma, D. Fruci, L. Finos, A. Frau, G. Morreale, A. Carrea, and G. M. Ghiggeri Angiotensin-converting enzyme (ACE) haplotypes and cyclosporine A (CsA) response: a model of the complex relationship between ACE quantitative trait locus and pathological phenotypes Hum. Mol. Genet., August 15, 2005; 14(16): 2357 - 2367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Meneton, X. Jeunemaitre, H. E. de Wardener, and G. A. Macgregor Links Between Dietary Salt Intake, Renal Salt Handling, Blood Pressure, and Cardiovascular Diseases Physiol Rev, April 1, 2005; 85(2): 679 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Klimes, K. Weston, D. Gasperikova, P. Kovacs, R. Kvetnansky, D. Jezova, R. Dixon, J. R. Thompson, E. Sebokova, and N. J. Samani Mapping of genetic determinants of the sympathoneural response to stress Physiol Genomics, January 20, 2005; 20(2): 183 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Wilder, M.-T. Bihoreau, K. Argoud, T. K. Watanabe, M. Lathrop, and D. Gauguier Integration of the Rat Recombination and EST Maps in the Rat Genomic Sequence and Comparative Mapping Analysis With the Mouse Genome Genome Res., April 1, 2004; 14(4): 758 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Mein, M. J. Caulfield, R. J. Dobson, and P. B. Munroe Genetics of essential hypertension Hum. Mol. Genet., April 1, 2004; 13(90001): R169 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J.L. Speirs and B. J. Morris WNK4 Intron 10 Polymorphism Is Not Associated With Hypertension Hypertension, April 1, 2004; 43(4): 766 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. L. Woo and I. Kurtz Mapping blood pressure loci in (A/J x B6)F2 mice Physiol Genomics, November 11, 2003; 15(3): 236 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Palijan, R. Lambert, J. Dutil, Z. Sivo, and A. Y. Deng Comprehensive Congenic Coverage Revealing Multiple Blood Pressure Quantitative Trait Loci on Dahl Rat Chromosome 10 Hypertension, October 1, 2003; 42(4): 515 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-K. Siegel, M. Planert, S. Rademacher, A. P. Mehr, P. Kossmehl, M. Wehland, M. Stoll, and R. Kreutz Genetic Loci Contribute to the Progression of Vascular and Cardiac Hypertrophy in Salt-Sensitive Spontaneous Hypertension Arterioscler Thromb Vasc Biol, July 1, 2003; 23(7): 1211 - 1217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Erlich, J. Cui, I. Chazaro, L. A. Farrer, C. T. Baldwin, H. Gavras, and A. L. DeStefano Genetic Variants of WNK4 in Whites and African Americans With Hypertension Hypertension, June 1, 2003; 41(6): 1191 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Monti, H. Zimdahl, H. Schulz, R. Plehm, D. Ganten, and N. Hubner The Role of Wnk4 in Polygenic Hypertension: A Candidate Gene Analysis on Rat Chromosome 10 Hypertension, April 1, 2003; 41(4): 938 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. McBride, F. J. Carr, D. Graham, N. H. Anderson, J. S. Clark, W. K. Lee, F. J. Charchar, M. J. Brosnan, and A. F. Dominiczak Microarray Analysis of Rat Chromosome 2 Congenic Strains Hypertension, March 1, 2003; 41(3): 847 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Mayosi, B. Keavney, A. Kardos, C. H. Davies, P. J. Ratcliffe, M. Farrall, and H. Watkins Electrocardiographic measures of left ventricular hypertrophy show greater heritability than echocardiographic left ventricular mass Eur. Heart J., December 2, 2002; 23(24): 1963 - 1971. [Abstract] [PDF]
|
|
|
|
|
|
F. Sugiyama, G. A. Churchill, R. Li, L. J. M. Libby, T. Carver, K.-I. Yagami, S. W. M. John, and B. Paigen QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice Physiol Genomics, July 12, 2002; 10(1): 5 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zimdahl, T. Kreitler, C. Gosele, D. Ganten, and N. Hubner Conserved Synteny in Rat and Mouse for a Blood Pressure QTL on Human Chromosome 17 Hypertension, June 1, 2002; 39(6): 1050 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S-Y Wu, C S J Fann, Y-S Jou, J-W Chen, and W-H Pan Association between markers in chromosomal region 17q23 and young onset hypertension: a TDT study J. Med. Genet., January 1, 2002; 39(1): 42 - 44. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Stoll, A. W. Cowley Jr., P. J. Tonellato, A. S. Greene, M. L. Kaldunski, R. J. Roman, P. Dumas, N. J. Schork, Z. Wang, and H. J. Jacob A Genomic-Systems Biology Map for Cardiovascular Function Science, November 23, 2001; 294(5547): 1723 - 1726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Francke, M. Manraj, C. Lacquemant, C. Lecoeur, F. Lepretre, P. Passa, A. Hebe, L. Corset, S. L. K. Yan, S. Lahmidi, et al. A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27 Hum. Mol. Genet., November 1, 2001; 10(24): 2751 - 2765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Garrett, X. Zhang, O. I. Dukhanina, A. Y. Deng, and J. P. Rapp Two Linked Blood Pressure Quantitative Trait Loci on Chromosome 10 Defined by Dahl Rat Congenic Strains Hypertension, October 1, 2001; 38(4): 779 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. HARRIS, M. STOLL, G. T. JONES, M. A. GRANADOS, W. K. PORTEOUS, A. M. VAN RIJ, and H. J. JACOB Identification of two susceptibility loci for vascular fragility in the Brown Norway rat Physiol Genomics, August 28, 2001; 6(3): 183 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. H. Wilson, S. Disse-Nicodeme, K. A. Choate, K. Ishikawa, C. Nelson-Williams, I. Desitter, M. Gunel, D. V. Milford, G. W. Lipkin, J.-M. Achard, et al. Human Hypertension Caused by Mutations in WNK Kinases Science, August 10, 2001; 293(5532): 1107 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. C. Luft and A. Busjahn Peaks and Valleys Hypertension, July 1, 2001; 38(1): 38 - 40. [Full Text] [PDF]
|
|
|
|
|
|
C. A. McKenzie, G. R. Abecasis, B. Keavney, T. Forrester, P. J. Ratcliffe, C. Julier, J. M.C. Connell, F. Bennett, N. McFarlane-Anderson, G. M. Lathrop, et al. Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE) Hum. Mol. Genet., May 1, 2001; 10(10): 1077 - 1084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Padmanabhan, S. Padmanabhan, and J. M. Connell Genetic basis of cardiovascular disease -- the renin-angiotensin-aldosterone system as a paradigm Journal of Renin-Angiotensin-Aldosterone System, December 1, 2000; 1(4): 316 - 324. [PDF]
|
|
|
|
|
|
L. Zagato, R. Modica, M. Florio, L. Torielli, M.-T. Bihoreau, G. Bianchi, and G. Tripodi Genetic Mapping of Blood Pressure Quantitative Trait Loci in Milan Hypertensive Rats Hypertension, November 1, 2000; 36(5): 734 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Rice, T. Rankinen, M. A. Province, Y. C. Chagnon, L. Perusse, I. B. Borecki, C. Bouchard, and D. C. Rao Genome-Wide Linkage Analysis of Systolic and Diastolic Blood Pressure : The Quebec Family Study Circulation, October 17, 2000; 102(16): 1956 - 1963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Levy, A. L. DeStefano, M. G. Larson, C. J. O'Donnell, R. P. Lifton, H. Gavras, L. A. Cupples, and R. H. Myers Evidence for a Gene Influencing Blood Pressure on Chromosome 17 : Genome Scan Linkage Results for Longitudinal Blood Pressure Phenotypes in Subjects From the Framingham Heart Study Hypertension, October 1, 2000; 36(4): 477 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Stoll, A. E. Kwitek-Black, A. W. Cowley Jr., E. L. Harris, S. B. Harrap, J. E. Krieger, M. P. Printz, A. P. Provoost, J. Sassard, and H. J. Jacob New Target Regions for Human Hypertension via Comparative Genomics Genome Res., April 1, 2000; 10(4): 473 - 482. [Abstract] [Full Text]
|
|
|
|
|
|
J. P. Rapp Genetic Analysis of Inherited Hypertension in the Rat Physiol Rev, January 1, 2000; 80(1): 135 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Dominiczak, D. C. Negrin, J. S. Clark, M. J. Brosnan, M. W. McBride, and M. Y. Alexander Genes and Hypertension : From Gene Mapping in Experimental Models to Vascular Gene Transfer Strategies Hypertension, January 1, 2000; 35(1): 164 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Wright, D. T. O'Connor, E. Roberts, G. Kutey, C. C. Berry, L. U. Yoneda, D. Timberlake, and G. Schlager Genome Scan for Blood Pressure Loci in Mice Hypertension, October 1, 1999; 34(4): 625 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Baima, M. Nicolaou, F. Schwartz, A. L. DeStefano, A. Manolis, I. Gavras, C. Laffer, F. Elijovich, L. Farrer, C. T. Baldwin, et al. Evidence for Linkage Between Essential Hypertension and a Putative Locus on Human Chromosome 17 Hypertension, July 1, 1999; 34(1): 4 - 7. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Corvol, A. Persu, A.-P. Gimenez-Roqueplo, and X. Jeunemaitre Seven Lessons From Two Candidate Genes in Human Essential Hypertension : Angiotensinogen and Epithelial Sodium Channel Hypertension, June 1, 1999; 33(6): 1324 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Glenn, W. Y. S. Wang, and B. J. Morris Different Frequencies of Inducible Nitric Oxide Synthase Genotypes in Older Hypertensives Hypertension, April 1, 1999; 33(4): 927 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Brosnan, J. S. Clark, B. Jeffs, C. D. Negrin, P. Van Vooren, S. M. Arribas, H. Carswell, T. J. Aitman, C. Szpirer, I. M. Macrae, et al. Genes Encoding Atrial and Brain Natriuretic Peptides as Candidates for Sensitivity to Brain Ischemia in Stroke-Prone Hypertensive Rats Hypertension, January 1, 1999; 33(1): 290 - 297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Brand, N. Chatelain, P. Mulatero, I. Fery, K. Curnow, X. Jeunemaitre, P. Corvol, L. Pascoe, and F. Soubrier Structural Analysis and Evaluation of the Aldosterone Synthase Gene in Hypertension Hypertension, August 1, 1998; 32(2): 198 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Soubrier Blood Pressure Gene at the Angiotensin I–Converting Enzyme Locus : Chronicle of a Gene Foretold Circulation, May 19, 1998; 97(18): 1763 - 1765. [Full Text] [PDF]
|
|
|
|
 |
|
 W.-Z. Ying, H. Xia, and P. W. Sanders Nitric Oxide Synthase (NOS2) Mutation in Dahl/Rapp Rats Decreases Enzyme Stability Circ. Res., August 17, 2001; 89(4): 317 - 322. [Abstract] [Full Text] [PDF]
|
|