Human Molecular Genetics, Vol 6, 2243-2246, Copyright © 1997 by Oxford University Press
K Mitsuya, H Sui, M Meguro, H Kugoh, Y Jinno, N Niikawa and M Oshimura
The Wilms' tumor suppressor gene ( WT1 ) was previously identified as being
imprinted, with frequent maternal expression in human placentae and fetal
brains. We examined the allele-specific expression of WT1 in cultured human
fibroblasts from 15 individuals. Seven of 15 fibroblast lines were
heterozygous for polymorphic alleles, and the expression patterns were
variable, i.e., equal, unequal or monoallelic paternal expression in three,
two and two cases, respectively. Exclusive paternal expression of WT1 was
also shown in non-cultured peripheral lymphocytes from the latter two
individuals. The allele-specific expression profiles of other imprinted
genes, IGF2 and H19, on human chromosome 11 were constant and consistent
with those in other tissues. Our unexpected observations of paternal or
biallelic expression of WT1 in fibroblasts and lymphocytes, together with
the previous findings of maternal or biallelic expression in placentae and
brains, suggest that the allele-specific regulatory system of WT1 is unique
and may be controlled by a putative tissue- and individual-specific
modifier.
ARTICLES
Paternal expression of WT1 in human fibroblasts and lymphocytes
Department of Molecular and Cell Genetics, School of Life Sciences, Faculty of Medicine, Tottori University, Nishimachi 86, Yonago, Tottori 683, Japan.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. P. Luedi, A. J. Hartemink, and R. L. Jirtle Genome-wide prediction of imprinted murine genes Genome Res., June 1, 2005; 15(6): 875 - 884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kobayashi, I. Ieiri, T. Hirota, H. Takane, S. Maegawa, J. Kigawa, H. Suzuki, E. Nanba, M. Oshimura, N. Terakawa, et al. FUNCTIONAL ASSESSMENT OF ABCG2 (BCRP) GENE POLYMORPHISMS TO PROTEIN EXPRESSION IN HUMAN PLACENTA Drug Metab. Dispos., January 1, 2005; 33(1): 94 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hirota, I. Ieiri, H. Takane, S. Maegawa, M. Hosokawa, K. Kobayashi, K. Chiba, E. Nanba, M. Oshimura, T. Sato, et al. Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status Hum. Mol. Genet., December 1, 2004; 13(23): 2959 - 2969. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Clement, F. T. Bosman, C. Fontolliet, and J. Benhattar Monoallelic Methylation of the APC Promoter Is Altered in Normal Gastric Mucosa Associated with Neoplastic Lesions Cancer Res., October 1, 2004; 64(19): 6867 - 6873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Bentley, K Nakabayashi, D Monk, C Beechey, J Peters, Z Birjandi, F E Khayat, M Patel, M A Preece, P Stanier, et al. The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome J. Med. Genet., April 1, 2003; 40(4): 249 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Blagitko, S. Mergenthaler, U. Schulz, H. A. Wollmann, W. Craigen, T. Eggermann, H.-H. Ropers, and V. M. Kalscheuer Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion Hum. Mol. Genet., July 1, 2000; 9(11): 1587 - 1595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Mitsuya, M. Meguro, M. P. Lee, M. Katoh, T. C. Schulz, H. Kugoh, M. A. Yoshida, N. Niikawa, A. P. Feinberg, and M. Oshimura LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids Hum. Mol. Genet., July 1, 1999; 8(7): 1209 - 1217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Falls, D. J. Pulford, A. A. Wylie, and R. L. Jirtle Genomic Imprinting: Implications for Human Disease Am. J. Pathol., March 1, 1999; 154(3): 635 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Greally Short interspersed transposable elements (SINEs) are excluded from imprinted regions in the human genome PNAS, January 8, 2002; 99(1): 327 - 332. [Abstract] [Full Text] [PDF]
|
|