Human Molecular Genetics, Vol 6, 487-495, Copyright © 1997 by Oxford University Press
EE Wanker, C Rovira, E Scherzinger, R Hasenbank, S Walter, D Tait, J Colicelli and H Lehrach
We report the discovery of the huntingtin interacting protein I (HIP-I)
which binds specifically to the N-terminus of human huntingtin, both in the
two-hybrid screen and in in vitro binding experiments. For the interaction
in vivo, a protein region downstream of the polyglutamine stretch in
huntingtin is essential. The HIP1 cDNA isolated by the two- hybrid screen
encodes a 55 kDa fragment of a novel protein. Using an affinity-purified
polyclonal antibody raised against recombinant HIP-I, a protein of 116 kDa
was detected in brain extracts by Western blot analysis. The predicted
amino acid sequence of the HIP-I fragment exhibits significant similarity
to cytoskeleton proteins, suggesting that HIP-I and huntingtin play a
functional role in the cell filament networks. The HIP1 gene is
ubiquitously expressed in different brain regions at low level. HIP-I is
enriched in human brain but can also be detected in other human tissues as
well as in mouse brain. HIP-I and huntingtin behave almost identically
during subcellular fractionation and both proteins are enriched in the
membrane containing fractions.
ARTICLES
HIP-I: a huntingtin interacting protein isolated by the yeast two- hybrid system
Max Planck Institut fur Molekulare Genetik, Berlin (Dahlem), Germany.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Zhang, M. B. Feany, S. Saraswati, J. T. Littleton, and N. Perrimon Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model Dis. Model. Mech., May 1, 2009; 2(5-6): 247 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Wilbur, C.-Y. Chen, V. Manalo, P. K. Hwang, R. J. Fletterick, and F. M. Brodsky Actin Binding by Hip1 (Huntingtin-interacting Protein 1) and Hip1R (Hip1-related Protein) Is Regulated by Clathrin Light Chain J. Biol. Chem., November 21, 2008; 283(47): 32870 - 32879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. Graves, S. T. Philips, S. V. Bradley, K. I. Oravecz-Wilson, L. Li, A. Gauvin, and T. S. Ross Use of a Cryptic Splice Site for the Expression of Huntingtin Interacting Protein 1 in Select Normal and Neoplastic Tissues Cancer Res., February 15, 2008; 68(4): 1064 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Poupon, M. Girard, V. Legendre-Guillemin, S. Thomas, L. Bourbonniere, J. Philie, N. A. Bright, and P. S. McPherson Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly PNAS, January 8, 2008; 105(1): 168 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Milnerwood and L. A. Raymond Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load J. Physiol., December 15, 2007; 585(3): 817 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Parker, M. Metzler, J. Georgiou, M. Mage, J. C. Roder, A. M. Rose, M. R. Hayden, and C. Neri Huntingtin-Interacting Protein 1 Influences Worm and Mouse Presynaptic Function and Protects Caenorhabditis elegans Neurons against Mutant Polyglutamine Toxicity J. Neurosci., October 10, 2007; 27(41): 11056 - 11064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Bradley, M. R. Smith, T. S. Hyun, P. C. Lucas, L. Li, D. Antonuk, I. Joshi, F. Jin, and T. S. Ross Aberrant Huntingtin Interacting Protein 1 in Lymphoid Malignancies Cancer Res., September 15, 2007; 67(18): 8923 - 8931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Lumsden, T. L. Henshall, S. Dayan, M. T. Lardelli, and R. I. Richards Huntingtin-deficient zebrafish exhibit defects in iron utilization and development Hum. Mol. Genet., August 15, 2007; 16(16): 1905 - 1920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Bradley, T. S. Hyun, K. I. Oravecz-Wilson, L. Li, E. I. Waldorff, A. N. Ermilov, S. A. Goldstein, C. X. Zhang, D. G. Drubin, K. Varela, et al. Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1 Hum. Mol. Genet., June 1, 2007; 16(11): 1279 - 1292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Meriin, X. Zhang, I. M. Alexandrov, A. B. Salnikova, M. D. Ter-Avanesian, Y. O. Chernoff, and M. Y. Sherman Endocytosis machinery is involved in aggregation of proteins with expanded polyglutamine domains FASEB J, June 1, 2007; 21(8): 1915 - 1925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Bradley, E. C. Holland, G. Y. Liu, D. Thomas, T. S. Hyun, and T. S. Ross Huntingtin Interacting Protein 1 Is a Novel Brain Tumor Marker that Associates with Epidermal Growth Factor Receptor Cancer Res., April 15, 2007; 67(8): 3609 - 3615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N.T. Strehlow, J. Z. Li, and R. M. Myers Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space Hum. Mol. Genet., February 15, 2007; 16(4): 391 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Trushina, R. D. Singh, R. B. Dyer, S. Cao, V. H. Shah, R. G. Parton, R. E. Pagano, and C. T. McMurray Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo Hum. Mol. Genet., December 15, 2006; 15(24): 3578 - 3591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Grelle, S. Kostka, A. Otto, B. Kersten, K. F. Genser, E.-C. Muller, S. Walter, A. Boddrich, U. Stelzl, C. Hanig, et al. Identification of VCP/p97, Carboxyl Terminus of Hsp70-interacting Protein (CHIP), and Amphiphysin II Interaction Partners Using Membrane-based Human Proteome Arrays Mol. Cell. Proteomics, February 1, 2006; 5(2): 234 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Jin, M. LaFevre-Bernt, Y. Sun, S. Chen, J. Gafni, D. Crippen, A. Logvinova, C. A. Ross, D. A. Greenberg, and L. M. Ellerby FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease PNAS, December 13, 2005; 102(50): 18189 - 18194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Liao, J. Shen, Y. Zhang, S.-H. Li, X.-J. Li, and H. Li Immunohistochemical Localization of Huntingtin-associated Protein 1 in Endocrine System of the Rat J. Histochem. Cytochem., December 1, 2005; 53(12): 1517 - 1524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Delalle, C. M. Pfleger, E. Buff, P. Lueras, and I. K. Hariharan Mutations in the Drosophila Orthologs of the F-Actin Capping Protein {alpha}- and {beta}-Subunits Cause Actin Accumulation and Subsequent Retinal Degeneration Genetics, December 1, 2005; 171(4): 1757 - 1765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Kegel, E. Sapp, J. Yoder, B. Cuiffo, L. Sobin, Y. J. Kim, Z.-H. Qin, M. R. Hayden, N. Aronin, D. L. Scott, et al. Huntingtin Associates with Acidic Phospholipids at the Plasma Membrane J. Biol. Chem., October 28, 2005; 280(43): 36464 - 36473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Ge, T. G. Chew, V. Wachtler, S. N. Naqvi, and M. K. Balasubramanian The Novel Fission Yeast Protein Pal1p Interacts with Hip1-related Sla2p/End4p and Is Involved in Cellular Morphogenesis Mol. Biol. Cell, September 1, 2005; 16(9): 4124 - 4138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. G. Mills, L. Gaughan, C. Robson, T. Ross, S. McCracken, J. Kelly, and D. E. Neal Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors J. Cell Biol., July 18, 2005; 170(2): 191 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Castagnetti, R. Behrens, and P. Nurse End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe J. Cell Sci., May 1, 2005; 118(9): 1843 - 1850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Y. Chen and F. M. Brodsky Huntingtin-interacting Protein 1 (Hip1) and Hip1-related Protein (Hip1R) Bind the Conserved Sequence of Clathrin Light Chains and Thereby Influence Clathrin Assembly in Vitro and Actin Distribution in Vivo J. Biol. Chem., February 18, 2005; 280(7): 6109 - 6117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Karapetian, A. G. Evstafieva, I. S. Abaeva, N. V. Chichkova, G. S. Filonov, Y. P. Rubtsov, E. A. Sukhacheva, S. V. Melnikov, U. Schneider, E. E. Wanker, et al. Nuclear Oncoprotein Prothymosin {alpha} Is a Partner of Keap1: Implications for Expression of Oxidative Stress-Protecting Genes Mol. Cell. Biol., February 1, 2005; 25(3): 1089 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Everett and N. W. Wood Trinucleotide repeats and neurodegenerative disease Brain, November 1, 2004; 127(11): 2385 - 2405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Ludewig, C. Kober-Eisermann, C. Weitzel, A. Bethke, K. Neubert, B. Gerisch, H. Hutter, and A. Antebi A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging Genes & Dev., September 1, 2004; 18(17): 2120 - 2133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Schilling, A. V. Savonenko, A. Klevytska, J. L. Morton, S. M. Tucker, M. Poirier, A. Gale, N. Chan, V. Gonzales, H. H. Slunt, et al. Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice Hum. Mol. Genet., August 1, 2004; 13(15): 1599 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. I. Oravecz-Wilson, M. J. Kiel, L. Li, D. S. Rao, D. Saint-Dic, P. D. Kumar, M. M. Provot, K. D. Hankenson, V. N. Reddy, A. P. Lieberman, et al. Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts Hum. Mol. Genet., April 15, 2004; 13(8): 851 - 867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Y. Engqvist-Goldstein, C. X. Zhang, S. Carreno, C. Barroso, J. E. Heuser, and D. G. Drubin RNAi-mediated Hip1R Silencing Results in Stable Association between the Endocytic Machinery and the Actin Assembly Machinery Mol. Biol. Cell, April 1, 2004; 15(4): 1666 - 1679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-H. Qin, Y. Wang, E. Sapp, B. Cuiffo, E. Wanker, M. R. Hayden, K. B. Kegel, N. Aronin, and M. DiFiglia Huntingtin Bodies Sequester Vesicle-Associated Proteins by a Polyproline-Dependent Interaction J. Neurosci., January 7, 2004; 24(1): 269 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chigira, K. Sugita, K. Kita, S. Sugaya, Y. Arase, M. Ichinose, H. Shirasawa, and N. Suzuki Increased Expression of the Huntingtin Interacting Protein-1 Gene in Cells From Hutchinson Gilford Syndrome (Progeria) Patients and Aged Donors J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2003; 58(10): B873 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Edwardson, C.-T. Wang, B. Gong, A. Wyttenbach, J. Bai, M. B. Jackson, E. R. Chapman, and A. J. Morton Expression of Mutant Huntingtin Blocks Exocytosis in PC12 Cells by Depletion of Complexin II J. Biol. Chem., August 15, 2003; 278(33): 30849 - 30853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xia, D. H. Lee, J. Taylor, M. Vandelft, and R. Truant Huntingtin contains a highly conserved nuclear export signal Hum. Mol. Genet., June 15, 2003; 12(12): 1393 - 1403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Okuda, H. Hattori, S. Takeuchi, J. Shimizu, H. Ueda, J. J. Palvimo, I. Kanazawa, H. Kawano, M. Nakagawa, and H. Okazawa PQBP-1 transgenic mice show a late-onset motor neuron disease-like phenotype Hum. Mol. Genet., April 1, 2003; 12(7): 711 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Einum, A. M. Clark, J. J. Townsend, L. J. Ptacek, and Y.-H. Fu A Novel Central Nervous System-Enriched Spinocerebellar Ataxia Type 7 Gene Product Arch Neurol, January 1, 2003; 60(1): 97 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Faber, C. Voisine, D. C. King, E. A. Bates, and A. C. Hart Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity PNAS, December 24, 2002; 99(26): 17131 - 17136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Modregger, N. A. DiProspero, V. Charles, D. A. Tagle, and M. Plomann PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains Hum. Mol. Genet., October 2, 2002; 11(21): 2547 - 2558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Henry, K. D'Hondt, J. Chang, T. Newpher, K. Huang, R. T. Hudson, H. Riezman, and S. K. Lemmon Scd5p and Clathrin Function Are Important for Cortical Actin Organization, Endocytosis, and Localization of Sla2p in Yeast Mol. Biol. Cell, August 1, 2002; 13(8): 2607 - 2625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, L.-S. Chin, A. I. Levey, and L. Li Huntingtin-associated Protein 1 Interacts with Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate and Functions in Endosomal Trafficking J. Biol. Chem., July 26, 2002; 277(31): 28212 - 28221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Legendre-Guillemin, M. Metzler, M. Charbonneau, L. Gan, V. Chopra, J. Philie, M. R. Hayden, and P. S. McPherson HIP1 and HIP12 Display Differential Binding to F-actin, AP2, and Clathrin. IDENTIFICATION OF A NOVEL INTERACTION WITH CLATHRIN LIGHT CHAIN J. Biol. Chem., May 24, 2002; 277(22): 19897 - 19904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hoffner, P. Kahlem, and P. Djian Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with {beta}-tubulin: relevance to Huntington's disease J. Cell Sci., January 3, 2002; 115(5): 941 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Mishra, N. R. Agostinelli, T. J. Brett, I. Mizukami, T. S. Ross, and L. M. Traub Clathrin- and AP-2-binding Sites in HIP1 Uncover a General Assembly Role for Endocytic Accessory Proteins J. Biol. Chem., November 30, 2001; 276(49): 46230 - 46236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Rao, J. C. Chang, P. D. Kumar, I. Mizukami, G. M. Smithson, S. V. Bradley, A. F. Parlow, and T. S. Ross Huntingtin Interacting Protein 1 Is a Clathrin Coat Binding Protein Required for Differentiation of late Spermatogenic Progenitors Mol. Cell. Biol., November 15, 2001; 21(22): 7796 - 7806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Metzler, V. Legendre-Guillemin, L. Gan, V. Chopra, A. Kwok, P. S. McPherson, and M. R. Hayden HIP1 Functions in Clathrin-mediated Endocytosis through Binding to Clathrin and Adaptor Protein 2 J. Biol. Chem., October 12, 2001; 276(42): 39271 - 39276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sathasivam, B. Woodman, A. Mahal, F. Bertaux, E. E. Wanker, D. T. Shima, and G. P. Bates Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients Hum. Mol. Genet., October 1, 2001; 10(21): 2425 - 2435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E.Y. Engqvist-Goldstein, R. A. Warren, M. M. Kessels, J. H. Keen, J. Heuser, and D. G. Drubin The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro J. Cell Biol., September 17, 2001; 154(6): 1209 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Waelter, E. Scherzinger, R. Hasenbank, E. Nordhoff, R. Lurz, H. Goehler, C. Gauss, K. Sathasivam, G. P. Bates, H. Lehrach, et al. The huntingtin interacting protein HIP1 is a clathrin and {alpha}-adaptin-binding protein involved in receptor-mediated endocytosis Hum. Mol. Genet., August 1, 2001; 10(17): 1807 - 1817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-S. Lebre, L. Jamot, J. Takahashi, N. Spassky, C. Leprince, N. Ravise, C. Zander, H. Fujigasaki, P. Kussel-Andermann, C. Duyckaerts, et al. Ataxin-7 interacts with a Cbl-associated protein that it recruits into neuronal intranuclear inclusions Hum. Mol. Genet., May 1, 2001; 10(11): 1201 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-L. Bang, R. E. Mudry, A. S. McElhinny, K. Trombitas, A. J. Geach, R. Yamasaki, H. Sorimachi, H. Granzier, C. C. Gregorio, and S. Labeit Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies J. Cell Biol., April 16, 2001; 153(2): 413 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Holbert, I. Denghien, T. Kiechle, A. Rosenblatt, C. Wellington, M. R. Hayden, R. L. Margolis, C. A. Ross, J. Dausset, R. J. Ferrante, et al. The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: Neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis PNAS, January 24, 2001; (2001) 41566798. [Abstract] [Full Text]
|
|
|
|
|
|
P. Hilditch-Maguire, F. Trettel, L. A. Passani, A. Auerbach, F. Persichetti, and M. E. MacDonald Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles Hum. Mol. Genet., November 1, 2000; 9(19): 2789 - 2797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Trettel, D. Rigamonti, P. Hilditch-Maguire, V. C. Wheeler, A. H. Sharp, F. Persichetti, E. Cattaneo, and M. E. MacDonald Dominant phenotypes produced by the HD mutation in STHdhQ111 striatal cells Hum. Mol. Genet., November 1, 2000; 9(19): 2799 - 2809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Passani, M. T. Bedford, P. W. Faber, K. M. McGinnis, A. H. Sharp, J. F. Gusella, J.-P. Vonsattel, and M. E. MacDonald Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis Hum. Mol. Genet., September 1, 2000; 9(14): 2175 - 2182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Davidson, B. Riley, E. N. Burright, L. A. Duvick, H. Y. Zoghbi, and H. T. Orr Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein Hum. Mol. Genet., September 1, 2000; 9(15): 2305 - 2312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shibata, D. P. Huynh, and S.-M. Pulst A novel protein with RNA-binding motifs interacts with ataxin-2 Hum. Mol. Genet., May 22, 2000; 9(9): 1303 - 1313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yanagisawa, M. Bundo, T. Miyashita, Y. Okamura-Oho, K. Tadokoro, K. Tokunaga, and M. Yamada Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine Hum. Mol. Genet., May 22, 2000; 9(9): 1433 - 1442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Metzler, C. D. Helgason, I. Dragatsis, T. Zhang, L. Gan, N. Pineault, S. O. Zeitlin, R. K. Humphries, and M. R. Hayden Huntingtin is required for normal hematopoiesis Hum. Mol. Genet., February 12, 2000; 9(3): 387 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E.Y. Engqvist-Goldstein, M. M. Kessels, V. S. Chopra, M. R. Hayden, and D. G. Drubin An Actin-Binding Protein of the Sla2/Huntingtin Interacting Protein 1 Family Is a Novel Component of Clathrin-Coated Pits and Vesicles J. Cell Biol., December 27, 1999; 147(7): 1503 - 1518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Boutell, P. Thomas, J. W. Neal, V. J. Weston, J. Duce, P. S. Harper, and A. L. Jones Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin Hum. Mol. Genet., September 1, 1999; 8(9): 1647 - 1655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yang, M. J. T. V. Cope, and D. G. Drubin Sla2p Is Associated with the Yeast Cortical Actin Cytoskeleton via Redundant Localization Signals Mol. Biol. Cell, July 1, 1999; 10(7): 2265 - 2283. [Abstract] [Full Text]
|
|
|
|
|
|
C.-A. Gutekunst, S.-H. Li, H. Yi, J. S. Mulroy, S. Kuemmerle, R. Jones, D. Rye, R. J. Ferrante, S. M. Hersch, and X.-J. Li Nuclear and Neuropil Aggregates in Huntington's Disease: Relationship to Neuropathology J. Neurosci., April 1, 1999; 19(7): 2522 - 2534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.J. T.V. Cope, S. Yang, C. Shang, and D. G. Drubin Novel Protein Kinases Ark1p and Prk1p Associate with and Regulate the Cortical Actin Cytoskeleton in Budding Yeast J. Cell Biol., March 22, 1999; 144(6): 1203 - 1218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Fusco, Q. Chen, W. J. Lamoreaux, G. Figueredo-Cardenas, Y. Jiao, J. A. Coffman, D. J. Surmeier, M. G. Honig, L. R. Carlock, and A. Reiner Cellular Localization of Huntingtin in Striatal and Cortical Neurons in Rats: Lack of Correlation with Neuronal Vulnerability in Huntington's Disease J. Neurosci., February 15, 1999; 19(4): 1189 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-A. Gutekunst, S.-H. Li, H. Yi, R. J. Ferrante, X.-J. Li, and S. M. Hersch The Cellular and Subcellular Localization of Huntingtin-Associated Protein 1 (HAP1): Comparison with Huntingtin in Rat and Human J. Neurosci., October 1, 1998; 18(19): 7674 - 7686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Li, Y. Nakagomi, Y. Kobayashi, D. E. Merry, F. Tanaka, M. Doyu, T. Mitsuma, Y. Hashizume, K. H. Fischbeck, and G. Sobue Nonneural Nuclear Inclusions of Androgen Receptor Protein in Spinal and Bulbar Muscular Atrophy Am. J. Pathol., September 1, 1998; 153(3): 695 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Li, S. H. Hosseini, C.-A. Gutekunst, S. M. Hersch, R. J. Ferrante, and X.-J. Li A Human HAP1 Homologue. CLONING, EXPRESSION, AND INTERACTION WITH HUNTINGTIN J. Biol. Chem., July 24, 1998; 273(30): 19220 - 19227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. S. Ross, O. A. Bernard, R. Berger, and D. G. Gilliland Fusion of Huntingtin Interacting Protein 1 to Platelet-Derived Growth Factor beta Receptor (PDGFbeta R) in Chronic Myelomonocytic Leukemia With t(5;7)(q33;q11.2) Blood, June 15, 1998; 91(12): 4419 - 4426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Li, C.-A. Gutekunst, S. M. Hersch, and X.-J. Li Interaction of Huntingtin-Associated Protein with Dynactin P150Glued J. Neurosci., February 15, 1998; 18(4): 1261 - 1269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I Dragatsis, A Efstratiadis, and S Zeitlin Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues Development, January 4, 1998; 125(8): 1529 - 1539. [Abstract] [PDF]
|
|
|
|
|
|
C. L. Wellington, R. Singaraja, L. Ellerby, J. Savill, S. Roy, B. Leavitt, E. Cattaneo, A. Hackam, A. Sharp, N. Thornberry, et al. Inhibiting Caspase Cleavage of Huntingtin Reduces Toxicity and Aggregate Formation in Neuronal and Nonneuronal Cells J. Biol. Chem., June 23, 2000; 275(26): 19831 - 19838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Peters and C. A. Ross Isolation of a 40-kDa Huntingtin-associated Protein J. Biol. Chem., January 26, 2001; 276(5): 3188 - 3194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Hackam, A. S. Yassa, R. Singaraja, M. Metzler, C.-A. Gutekunst, L. Gan, S. Warby, C. L. Wellington, J. Vaillancourt, N. Chen, et al. Huntingtin Interacting Protein 1 Induces Apoptosis via a Novel Caspase-dependent Death Effector Domain J. Biol. Chem., December 22, 2000; 275(52): 41299 - 41308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Holbert, I. Denghien, T. Kiechle, A. Rosenblatt, C. Wellington, M. R. Hayden, R. L. Margolis, C. A. Ross, J. Dausset, R. J. Ferrante, et al. The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: Neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis PNAS, February 13, 2001; 98(4): 1811 - 1816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-L. Bang, T. Centner, F. Fornoff, A. J. Geach, M. Gotthardt, M. McNabb, C. C. Witt, D. Labeit, C. C. Gregorio, H. Granzier, et al. The Complete Gene Sequence of Titin, Expression of an Unusual {approx}700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System Circ. Res., November 23, 2001; 89(11): 1065 - 1072. [Abstract] [Full Text] [PDF]
|
|