Human Molecular Genetics, Vol 6, 1137-1145, Copyright © 1997 by Oxford University Press
E Montini, EI Rugarli, E Van de Vosse, G Andolfi, M Mariani, AA Puca, GG Consalez, JT den Dunnen, A Ballabio and B Franco
Through our transcriptional mapping effort in the Xp22 region, we have
isolated by exon trapping a new transcript highly homologous to the
Drosophila retinal degeneration C (rdgC) gene. rdgC encodes a
serine/threonine phosphatase protein and is required in Drosophila to
prevent light-induced retinal degeneration. This human gene is the first
mammalian member of the serine-threonine phosphatase with EF hand motif
gene family, and was thus named PPEF (Protein Phosphatase with EF
calcium-binding domain). The expression pattern of the mouse Ppef gene was
studied by RNA in situ hybridization on embryonic tissue sections. While
rdgC is expressed in the visual system of the fly, as well as in the
mushroom bodies of the central brain, we found that Ppef is highly
expressed in sensory neurons of the dorsal root ganglia (DRG) and neural
crest-derived cranial ganglia. The selective pattern of expression makes
PPEF an important marker for sensory neuron differentiation and suggests a
role for serine-threonine phosphatases in mammalian development.
ARTICLES
A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin
Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milan, Italy.
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