Human Molecular Genetics, Vol 7, 1599-1609, Copyright © 1998 by Oxford University Press
IM Morison and AE Reeve
Parent-of-origin effects were first recorded >3000 years ago by mule
breeders in Asia Minor. There are now several different types of evidence
suggesting the presence of a large number of imprinted genes, many of which
have not yet been identified. Here, we catalogue a wide range of evidence
and phenomena which indicate or suggest the presence of genomic imprinting
in animals. This evidence includes: the direct documentation of
parent-of-origin-specific gene transcription; human disease inheritance
patterns which suggest the involvement of imprinted genes; and older, less
well studied animal models which may show parent- of-origin effects.
REVIEWS
A catalogue of imprinted genes and parent-of-origin effects in humans and animals
Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand. morison@sanger.otago.ac.nz
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