Human Molecular Genetics, Vol 8, 1409-1415, Copyright © 1999 by Oxford University Press
M Ema, S Ikegami, T Hosoya, J Mimura, H Ohtani, K Nakao, K Inokuchi, M Katsuki and Y Fujii-Kuriyama
Human Sim2 is a product of one of the genes located on human chromosome
21q22 and is a homolog of Drosophila single-minded ( sim ) which is a
critical player in midline development of the central nervous system of the
fly. Since Sim2 mRNA is expressed in facial, skull, palate and vertebra
primordia in human and rodent embryos, features that are associated with
phenotypes of Down's syndrome (DS), its trisomic state is suspected to
contribute to the symptoms of DS. Here we describe that mSim2 mRNA is
expressed in hippocampus and amygdala of adult mice, and that while mice
overexpressing mSim2 under the control of the beta- actin promoter are
viable and fertile and have superficially normal skeletal, brain and heart
structures, they exhibit a moderate defect in context-dependent fear
conditioning and a mild defect in the Morris water maze test. Taken
together, our data show that overdosage of Sim2 may be important for the
pathogenesis of Down's syndrome, especially mental retardation.
ARTICLES
Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan,
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