Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (80)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Cookson, W. O.C.
Right arrow Articles by Moffatt, M. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cookson, W. O.C.
Right arrow Articles by Moffatt, M. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, 2000, Vol. 9, No. 16 2359-2364
© 2000 Oxford University Press

Genetics of asthma and allergic disease

William O.C. Cookson+ and Miriam F. Moffatt

Asthma Genetics Group, Wellcome Trust Centre for Human Genetic Disease, Roosevelt Drive, Headington, Oxford OX3 7BN, UK

Atopic (allergic) asthma is the most common disease of childhood and is strongly genetic in origin. Many genome-wide screens for asthma and its associated traits have now been carried out, and genetic linkage has been consistently identified in several regions. It is probable that these loci contain major genes influencing atopy and asthma. Candidate genes have already been identified from the cytokine cluster on chromosome 5 and the MHC on chromosome 6. These complex regions contain more than one susceptibility locus for allergic disease. Other regions do not contain obvious candidate genes, and positional cloning of these loci is likely to identify novel disease pathways. Parent-of-origin effects are prominent at some of the loci and some also show linkage to other inflammatory immune diseases. Several single gene disorders are associated with allergic disease and on occasion are also linked to the same chromosomal regions. The positional cloning of asthma genes is now feasible.

+ To whom correspondence should be addressed. Tel: +44 1865 287 607; Fax: +44 1865 287 678; Email: wocc@well.ox.ac.uk


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
J. H. White, M. Chiano, M. Wigglesworth, R. Geske, J. Riley, N. White, S. Hall, G. Zhu, F. Maurio, T. Savage, et al.
Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation
Hum. Mol. Genet., July 1, 2008; 17(13): 1890 - 1903.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
T. J. Corydon, A. Haagerup, T. G. Jensen, H. G. Binderup, M. S. Petersen, K. Kaltoft, J. Vestbo, T. A. Kruse, and A. D. Borglum
A functional CD86 polymorphism associated with asthma and related allergic disorders
J. Med. Genet., August 1, 2007; 44(8): 509 - 515.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Harada, K. Nakashima, T. Hirota, M. Shimizu, S. Doi, K. Fujita, T. Shirakawa, T. Enomoto, M. Yoshikawa, H. Moriyama, et al.
Functional Polymorphism in the Suppressor of Cytokine Signaling 1 Gene Associated with Adult Asthma
Am. J. Respir. Cell Mol. Biol., April 1, 2007; 36(4): 491 - 496.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Family NursingHome page
K. Koenig
Families Discovering Asthma in Their High-Risk Infants and Toddlers With Severe Persistent Disease
Journal of Family Nursing, February 1, 2006; 12(1): 56 - 79.
[Abstract] [PDF]

Home page
 Hum Mol GenetHome page
E. Bitoun, A. Micheloni, L. Lamant, C. Bonnart, A. Tartaglia-Polcini, C. Cobbold, T. Al Saati, F. Mariotti, J. Mazereeuw-Hautier, F. Boralevi, et al.
LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome
Hum. Mol. Genet., October 1, 2003; 12(19): 2417 - 2430.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
B. A. Raby, E. K. Silverman, R. Lazarus, C. Lange, D. J. Kwiatkowski, and S. T. Weiss
Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes
Hum. Mol. Genet., August 15, 2003; 12(16): 1973 - 1979.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. D. Gilliland, Y.-F. Li, L. Dubeau, K. Berhane, E. Avol, R. McConnell, W. J. Gauderman, and J. M. Peters
Effects of Glutathione S-Transferase M1, Maternal Smoking during Pregnancy, and Environmental Tobacco Smoke on Asthma and Wheezing in Children
Am. J. Respir. Crit. Care Med., August 15, 2002; 166(4): 457 - 463.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. T. Weiss
Association Studies in Asthma Genetics
Am. J. Respir. Crit. Care Med., December 1, 2001; 164(11): 2014 - 2015.
[Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T. Niimi, C. L. Keck-Waggoner, N. C. Popescu, Y. Zhou, R. C. Levitt, and S. Kimura
UGRP1, a Uteroglobin/Clara Cell Secretory Protein-Related Protein, Is a Novel Lung-Enriched Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor
Mol. Endocrinol., November 1, 2001; 15(11): 2021 - 2036.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
J. A. MacLean and F. J. Eidelman
The Genetics of Atopy and Atopic Eczema
Arch Dermatol, November 1, 2001; 137(11): 1474 - 1476.
[Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
G Koeppen-Schomerus, J Stevenson, and R Plomin
Genes and environment in asthma: a study of 4 year old twins
Arch. Dis. Child., November 1, 2001; 85(5): 398 - 400.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
J-C Renauld
New insights into the role of cytokines in asthma
J. Clin. Pathol., August 1, 2001; 54(8): 577 - 589.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.