Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (44)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Faiella, A.
Right arrow Articles by Nadeau, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Faiella, A.
Right arrow Articles by Nadeau, J. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, 2000, Vol. 9, No. 2 227-236
© 2000 Oxford University Press

A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression

Antonio Faiella+, Marius Wernig2,+, G. Giacomo Consalez1, Ute Hostick2, Clementine Hofmann2, Elisabeth Hustert2, Edoardo Boncinelli1, Rudi Balling2 and Joseph H. Nadeau3,§

DIBIT and 1Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy, 2Institut für Säugetiergenetik, GSF-Forschungszentrum für Umwelt und Gesundheit, D-85758, Neuherberg, Germany, 3Department of Genetics, Case Western Reserve University School of Medicine and Center for Human Genetics, University Hospitals of Cleveland, Cleveland, OH 44106, USA

Valproate (VPA) is one of several effective anti-epileptic and mood-stabilizing drugs, many of which are also potent teratogens in humans and several other mammalian species. Variable teratogenicity among inbred strains of laboratory mice suggests that genetic factors influence susceptibility. While studying the genetic basis for VPA teratogenicity in mice, we discovered that parental factors influence fetal susceptibility to induced malformations. Detailed examination of these malformations revealed that many were homeotic transformations. To test whether VPA, like retinoic acid (RA), alters HOX expression, pluripotent human embryonal carcinoma cells were treated with VPA or RA and Hox expression assessed. Altered expression of specific Hox genes may thus account for the homeotic transformations and other malformations found in VPA-treated fetuses.

+ These authors contributed equally to this work

§ To whom correspondence should be addressed at: Department of Genetics, BRB-630, CWRU, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Tel: +1 216 368 0581; Fax: +1 216 368 3432; Email: jhn4@po.cwru.edu


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Phil Trans R Soc BHome page
B. M. Turner
Epigenetic responses to environmental change and their evolutionary implications
Phil Trans R Soc B, November 27, 2009; 364(1534): 3403 - 3418.
[Abstract] [Full Text] [PDF]

Home page
 PNHome page
J. J Craig and S. J Hunt
Treating women with juvenile myoclonic epilepsy
Practical Neurology, October 1, 2009; 9(5): 268 - 277.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Towers and C. Tickle
Growing models of vertebrate limb development
Development, January 15, 2009; 136(2): 179 - 190.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
F. Di Renzo, M. L. Broccia, E. Giavini, and E. Menegola
Relationship between Embryonic Histonic Hyperacetylation and Axial Skeletal Defects in Mouse Exposed to the Three HDAC Inhibitors Apicidin, MS-275, and Sodium Butyrate
Toxicol. Sci., August 1, 2007; 98(2): 582 - 588.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
L. G. Costa, L. Steardo, and V. Cuomo
Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects
Pharmacol. Rev., March 1, 2004; 56(1): 103 - 147.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Iezzi, G. Cossu, C. Nervi, V. Sartorelli, and P. L. Puri
Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases
PNAS, May 28, 2002; 99(11): 7757 - 7762.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
J C S Dean, H Hailey, S J Moore, D J Lloyd, P D Turnpenny, and J Little
Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth
J. Med. Genet., April 1, 2002; 39(4): 251 - 259.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
M R JOHNSON, M R JOHNSON, J W A S SANDER, and J W A S SANDER
The clinical impact of epilepsy genetics
J. Neurol. Neurosurg. Psychiatry, April 1, 2001; 70(4): 428 - 430.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.