Human Molecular Genetics Advance Access published online on July 1, 2003
Human Molecular Genetics, doi:10.1093/hmg/ddg206
© 2003 by Oxford University Press
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1 Department of Endocrinology, Malmö University Hospital, SE-205 02, Malmö, Sweden
* To whom correspondence should be addressed. E-mail: olle.melander{at}endo.mas.lu.se.
With the aim to identify hypertension susceptibility loci we performed a genome wide scan in Scandinavian sib-pairs with early onset primary hypertension. To be classified as affected, a diagnosis of primary hypertension at age Our data suggest a hypertension susceptibility locus on chromosome 14 around 41 cM. The locus on chromosome 2 is also promising as it has been implicated in hypertension and blood pressure regulation in earlier genome scans.
Article
A Genome Wide Scan for Early Onset Primary Hypertension in Scandinavians
2 Department of Endocrinology, Malmö University Hospital, SE-205 02, Malmö, Sweden; Department of Community Medicine, Malmö University Hospital, SE-205 02, Malmö, Sweden
3 Department of Medicine, Division of Internal Medicine, Helsinki University Central Hospital, FI-00029, Helsinki, Finland
4 Department of Community Medicine, Malmö University Hospital, SE-205 02, Malmö, Sweden
5 Department of Medicine, Hospital of Helsingborg, SE-251 87 Helsingborg, Sweden
6 Department of Endocrinology, Wallenberg laboratory, Entrance 46, floor 3, Malmö University Hospital MAS, SE-205 02 MALMÖ, Sweden
Abstract 
50 years was required. Two hundred and forty-three patients with onset of primary hypertension at 40.0 ± 7.7 (mean ± SD) years from 91 families (91 sib-ships with a mean of 2.7 and a range of 2-6 affected members per sib-ship) were genotyped with 362 microsatellite markers with a density of 
10 cM. Loci obtaining nominal P 0.016 (LOD score 
1.0) were fine mapped with additional markers. Multipoint non-parametric linkage analysis was performed using GENEHUNTER v.2.0. By simulations, a nominal P 0.0002 was determined to be genome wide significant evidence of linkage. In the 10 cM genome wide scan, nominal P 0.016 were found on chromosomes 1 at 81 cM (P = 0.007), 2 at 115 cM (P = 0.006), 3 at 108 cM (P = 0.006), 14 at 45 cM (P = 0.0002) and at 99 cM (P = 0.001), 17 at 42 cM (P = 0.015) and 19 at 89 cM (P = 0.007). After fine mapping of these loci, one of the chromosome 14 loci just obtained the level of genome wide significance (P = 0.0002 at 41 cM) and the chromosome 2 locus reached suggestive evidence of linkage (P = 0.002 at 118 cM).
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