Skip Navigation



Human Molecular Genetics Advance Access published online on July 8, 2003
Human Molecular Genetics, doi:10.1093/hmg/ddg221
© 2003 by Oxford University Press
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
12/17/2191    most recent
ddg221v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Bomprezzi, R.
Right arrow Articles by Trent, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bomprezzi, R.
Right arrow Articles by Trent, J. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

©2003 Oxford University Press

Article

Gene Expression Profile in Multiple Sclerosis Patients and Healthy Controls: Identifying Pathways Relevant to Disease

Roberto Bomprezzi 1*, Markus Ringnér 2, Seungchan Kim 3, Michael L. Bittner 3, Javed Khan 4, Yidong Chen 5, Abdel Elkahloun 5, Aimee Yu 6, Bibiana Bielekova 6, Paul S. Meltzer 5, Roland Martin 6, Henry F. McFarland 6, and Jeffrey M. Trent 7

1 Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Bldg 50 Room 5150, Bethesda, Maryland 20892, USA
2 Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; Dept. of Theoretical Physics, Lund University, SE-223 62 Lund, Sweden
3 Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; Translational Genomics Research Institute, Phoenix, Arizona 85004, USA
4 Advanced Technology Center, National Cancer Institute, National Institutes of Health, Gaithersburg, Maryland 20877, USA
5 Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
6 Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
7 Translational Genomics Research Institute, Phoenix, Arizona 85004, USA

* To whom correspondence should be addressed. E-mail: rbomprez{at}nhgri.nih.gov.


  Abstract

Multiple sclerosis (MS) and other T cell-mediated autoimmune diseases develop in individuals carrying a complex susceptibility trait, probably following exposure to various environmental triggers. Due to the presumed weak influence of single genes on disease predisposition and the recognized genetic heterogeneity of autoimmune disorders in humans, candidate gene searches in MS have been difficult. In an attempt to identify molecular markers indicative of disease status rather than susceptibility genes for MS, we show that gene expression profiling of peripheral blood mononuclear cells by cDNA microarrays can distinguish MS patients from healthy controls. Our findings support the concept that the activation of autoreactive T cells is of primary importance for this complex organ-specific disorder and prompt further investigations on gene expression in peripheral blood cells aimed at characterizing disease phenotypes.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BioinformaticsHome page
A.-L. Boulesteix, C. Porzelius, and M. Daumer
Microarray-based classification and clinical predictors: on combined classifiers and additional predictive value
Bioinformatics, August 1, 2008; 24(15): 1698 - 1706.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. Bouwens, L. A Afman, and M. Muller
Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid {beta}-oxidation: functional role of peroxisome proliferator activated receptor {alpha} in human peripheral blood mononuclear cells
Am. J. Clinical Nutrition, November 1, 2007; 86(5): 1515 - 1523.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
S. C. Fossey, C. L. Vnencak-Jones, N. J. Olsen, S. Sriram, G. Garrison, X. Deng, P. S. Crooke III, and T. M. Aune
Identification of Molecular Biomarkers for Multiple Sclerosis
J. Mol. Diagn., April 1, 2007; 9(2): 197 - 204.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Preller, A. Gerber, S. Wrenger, M. Togni, D. Marguet, J. Tadje, U. Lendeckel, C. Rocken, J. Faust, K. Neubert, et al.
TGF-beta1-Mediated Control of Central Nervous System Inflammation and Autoimmunity through the Inhibitory Receptor CD26
J. Immunol., April 1, 2007; 178(7): 4632 - 4640.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
F. R. Sharp, H. Xu, L. Lit, W. Walker, M. Apperson, D. L. Gilbert, T. A. Glauser, B. Wong, A. Hershey, D.-Z. Liu, et al.
The Future of Genomic Profiling of Neurological Diseases Using Blood
Arch Neurol, November 1, 2006; 63(11): 1529 - 1536.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
F. K. Tan, X. Zhou, M. D. Mayes, P. Gourh, X. Guo, C. Marcum, L. Jin, and F. C. Arnett Jr
Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients
Rheumatology, June 1, 2006; 45(6): 694 - 702.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Chon, M. C. Verhaar, H. A. Koomans, J. A. Joles, and B. Braam
Role of Circulating Karyocytes in the Initiation and Progression of Atherosclerosis
Hypertension, May 1, 2006; 47(5): 803 - 810.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
Z. Liu, K. Maas, and T. M. Aune
Identification of gene expression signatures in autoimmune disease without the influence of familial resemblance
Hum. Mol. Genet., February 1, 2006; 15(3): 501 - 509.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
B. Bielekova, N. Kadom, E. Fisher, N. Jeffries, J. Ohayon, N. Richert, T. Howard, C. N. Bash, J. A. Frank, L. Stone, et al.
MRI as a marker for disease heterogeneity in multiple sclerosis
Neurology, October 11, 2005; 65(7): 1071 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
Y. Wang, F. S. Makedon, J. C. Ford, and J. Pearlman
HykGene: a hybrid approach for selecting marker genes for phenotype classification using microarray gene expression data
Bioinformatics, April 15, 2005; 21(8): 1530 - 1537.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. F. Moore, H. Li, N. Jeffries, V. Wright, R. A. Cooper Jr, A. Elkahloun, M. P. Gelderman, E. Zudaire, G. Blevins, H. Yu, et al.
Using Peripheral Blood Mononuclear Cells to Determine a Gene Expression Profile of Acute Ischemic Stroke: A Pilot Investigation
Circulation, January 18, 2005; 111(2): 212 - 221.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
N Olsen, T Sokka, C L Seehorn, B Kraft, K Maas, J Moore, and T M Aune
A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells
Ann Rheum Dis, November 1, 2004; 63(11): 1387 - 1392.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
B. Bielekova and R. Martin
Development of biomarkers in multiple sclerosis
Brain, July 1, 2004; 127(7): 1463 - 1478.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.