Human Molecular Genetics Advance Access published online on July 29, 2003
Human Molecular Genetics, doi:10.1093/hmg/ddg251
© 2003 by Oxford University Press
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1 Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
* To whom correspondence should be addressed. E-mail: m.j.lercher{at}bath.ac.uk.
The human genome is a mosaic structure on many levels: there exist cytogenetic bands, GC composition bands (isochores) and clusters of broadly expressed genes. How might these inter-relate? It has been proposed that to optimise gene regulation, housekeeping genes should concentrate on transcriptionally competent chromosomal domains. Prior evidence suggests that regions of high GC and R bands are associated with such domains. Here we report that broadly expressed genes cluster in regions of high GC, and in R and lightest Giemsa bands. This is not only a confirmation of the adaptive hypothesis, but is also the first direct systematic evidence of a general interdependence of expression patterns with base composition and chromosome structure.
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A unification of mosaic structures in the human genome
ek 2,
2 Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 16637 Prague, Czech Republic
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