Skip Navigation



Human Molecular Genetics Advance Access published online on July 29, 2003
Human Molecular Genetics, doi:10.1093/hmg/ddg252
© 2003 by Oxford University Press
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
12/19/2511    most recent
ddg252v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Cader, Z. M
Right arrow Articles by Ebers, G. C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cader, Z. M
Right arrow Articles by Ebers, G. C
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

©2003 Oxford University Press

Article

Significant Linkage to Migraine with Aura on Chromosome 11q24

Zameel M Cader 1, Sandra Noble-Topham 2, David A Dyment 1, Stacey S Cherny 1, John D Brown 3, George PA Rice 3, and George C Ebers 4*

1 Wellcome Trust Centre for Human Genetics, Oxford, UK, OX3 7BN
2 Lawson Health Sciences Research Institute, London Health Sciences Centre, London, Canada
3 Department of Clinical Neurology, London Health Sciences Centre, London, Canada
4 Department of Clinical Neurology, University of Oxford Radcliffe Infirmary, Woodstock Road, Oxford, UK, OX2 6HE

* To whom correspondence should be addressed. E-mail: george.ebers{at}clneuro.ox.ac.uk.


  Abstract

Migraine with aura (MA) is a prevalent neurological condition with strong evidence for a genetic basis. Familial hemiplegic migraine, a rare Mendelian form of MA can be caused by mutations in the calcium channel gene, CACNA1A or in the ATP1A2 gene, a Na+/K+ pump. Susceptibility genes for the more prevalent forms of migraine have yet to be identified despite several reports of linkage including loci on 4q24, 1q31, 19p13 and Xq24-28.

We have undertaken a genome wide screen of 43 Canadian families segregating MA with families chosen for an apparent autosomal dominant pattern of transmission. Diagnosis was based upon International Headache Society Criteria.

Parametric linkage analysis revealed a novel locus on 11q24 with a two-point LOD score of 4.2 and a multi-point parametric LOD score of 5.6. We did not find any support for linkage at previously reported loci.

The lack of consensus amongst linkage studies, including this study, is probably an indication of the heterogeneity that is inherent for MA. Nevertheless, the finding of a highly significant locus with a LOD score of 5.6 is powerful evidence that a gene increasing susceptibility to MA resides on 11q24. Several candidate genes map to this region of the genome including a number of ion channel genes such as GRIK4, SCNB2, KCNJ5 and KCNJ1.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
H. Lee, J. C. Jen, H. Wang, Z. Chen, H. Mamsa, C. Sabatti, R. W. Baloh, and S. F. Nelson
A genome-wide linkage scan of familial benign recurrent vertigo: linkage to 22q12 with evidence of heterogeneity
Hum. Mol. Genet., January 15, 2006; 15(2): 251 - 258.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.