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Human Molecular Genetics Advance Access published online on August 5, 2003
Human Molecular Genetics, doi:10.1093/hmg/ddg257
© 2003 by Oxford University Press
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©2003 Oxford University Press

Article

The Newfoundland Population: A Unique Resource for Genetic Investigation of Complex Diseases

Proton Rahman 1*, Albert Jones 2, Joseph Curtis 3, Sylvia Bartlett 4, Lynette Peddle 4, Bridget A Fernandez 5, and Nelson B Freimer 6

1 Department of Medicine, St Clare's Mercy Hospital, Memorial University of Newfoundland, 1 South, 154 LeMarchant Rd, St. John's, Newfoundland, Canada A1C - 5B8; Department of Genetics, Memorial University of Newfoundland, St. John's Newfoundland
2 Department of History, Memorial University of Newfoundland, St. John's Newfoundland
3 Department of Pediatrics, Memorial University of Newfoundland, St. John's Newfoundland
4 Newfound Genomics, UCLA, 187 LeMarchant Rd, St. John's Newfoundland
5 Department of Genetics, Memorial University of Newfoundland, St. John's Newfoundland
6 Center for Neurobehavioral Genetics, Departments of Psychiatry and Human Genetics, UCLA, Los Angeles, CA

* To whom correspondence should be addressed. E-mail: prahman{at}mun.ca.


  Abstract

The population of the province of Newfoundland and Labrador is genetically isolated. This isolation is evidenced by an overabundance of several monogenic disorders. The Newfoundland population, like that of other isolates, is now the focus of interest for identification of genes implicated in common diseases. However, the utility of such populations for this purpose remains unproven. In this paper, we review the current genetic architecture of the province, with respect to geographic isolation, homogeneity, founder effect, genetic drift, and extended linkage disequilibrium. Based on these factors, we propose that the population of Newfoundland offers many advantages for genetic mapping of common diseases, compared with admixed populations, and even compared with other isolates.


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